Xiyao Yang,1,* Alayi Bolatai,2,* Jiaxin An,2 Na Wu1,3 

1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, People’ s Republic of China; 2Department of Student Affairs, Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, People’ s Republic of China; 3Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, People’ s Republic of China

*These authors contributed equally to this work

Correspondence: Na Wu, Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, People’ s Republic of China, Email 3441535223@qq.com

Abstract: With changes in lifestyle, sedentary behavior or lack of physical exercise increases the risk of various glycolipid metabolic disorders. Glycolipid metabolic dysregulation refers to abnormalities in the metabolism of carbohydrates and lipids, including diseases such as diabetes, obesity, and metabolic syndrome. In-depth research into the molecular mechanisms of glycolipid metabolic dysregulation can help develop more effective treatment strategies and preventive measures to prevent the occurrence of long-term complications such as cardiovascular diseases. Alternative polyadenylation (APA) is an important form of RNA modification that helps regulate gene expression and generate protein diversity. This modification can affect processes such as RNA stability, post-transcriptional modification, and translational regulation. Recent studies have confirmed that APA can influence the expression of genes involved in glucose and lipid metabolism, increasing the probability of developing immune, endocrine, and metabolic diseases. The review explains the research progress of APA involvement in various metabolic diseases and explores these mechanisms, providing new insights and directions for novel metabolic disorder treatment strategies.

Keywords: APA, alternative polyadenylation, glycolipid metabolic diseases, 3’UTRs, diabetes, obesity, metabolism, dysfunction