Wenzhi Zhu,1,* Jiaonan Yang,1,* Xiaoyi Wang,2 Xinqiang Ji,2 Hongyu Tan1 

1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute, Beijing, People’s Republic of China; 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Medical Record Statistics, Peking University Cancer Hospital& Institute, Beijing, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Hongyu Tan, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing, 100142, People’s Republic of China, Tel +86-13693564036, Email galaxyspark@163.com

Background: People in China have gradually entered old age society, and the number of lung cancer cases is expected to increase annually among the elderly. This study aimed to retrospectively explore the association between perioperative factors and short-term outcomes in elderly patients with non-small cell lung cancer (NSCLC).
Methods: A total of 490 elderly patients with NSCLC between January 1, 2003, and December 31, 2009, were selected. Perioperative factors were grouped and analyzed according to postoperative complications (PPCs) and length of hospital stay. A logistic regression analysis model was used to screen for the independent predictors of patient prognosis. The primary endpoint was postoperative complications and the secondary endpoint was postoperative hospital stay.
Results: Of all patients, 344 (70.2%) developed postoperative complications, and the average length of stay after surgery was 14.0± 5.6 days. Perioperative fentanyl equivalents> 28.7μg/kg and duration of surgery> 4.4h were associated were associated with an increased risk of postoperative complications (P < 0.05); intraoperative blood loss (IBL) > 200 mL was associated with extended hospital stay (P < 0.05).
Conclusion: This study suggested that Perioperative factors may affect the short-term prognosis of elderly NSCLC patients after surgery. Perioperative fentanyl equivalents> 28.7μg/kg, surgery duration, and IBL may be independent predictors of short-term outcomes in elderly patients.

Keywords: perioperative factor, NSCLC, outcome, opioid, the elderly