Jiahao Guan,1,* Yihan Dong,1,2,* Wenli Zhang,3 Qiaodi Gui,1 Danxia Luo,4 Hongxia Wen,5 Xiaojun Dang,1 Daoyan Liang,1 Shuling Hu,1 Yaqin Zhang,1 Guimei Liao,2 Lixia Zhang,1 Zifan Lu6 

1Department of Clinical Laboratory, Shaanxi Provincial People′s Hospital, Xi ′an, 710068, People’s Republic of China; 2Medical College, Yan’ an University, Yan’ an, Shaanxi, 716000, People’s Republic of China; 3Translational Medicine Center of Shaanxi Provincial People’s Hospital; Shaanxi Province Research Center of Cell Immunological Engineering and Technology, Xi’an, 710068, People’s Republic of China; 4The Gynecology Department of People’s Hospital of Shaanxi Province, Xi’an, 710068, People’s Republic of China; 5Department of Respiratory Medicine II, Shaanxi Provincial People’s Hospital, Xi’an, 710068, People’s Republic of China; 6Translational Medicine Center of Shaanxi Provincial People’s Hospital, Xi’an, 710068, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Lixia Zhang; Zifan Lu, Shaanxi Provincial People′s Hospital, No. 256, Youyi West Road, Xi’an, Shaanxi Province, People’s Republic of China, Tel +86 029-85251331, Email 17791735548@163.com; pharmluzifan@163.com

Background: Vaginitis is a common disease of the reproductive system in women, causing discomfort in daily life. Many reports indicate that the causes of vaginitis are related to vaginal microecological disturbances. Therefore, treatment strategies to restore microecological balance have shown promising results in both basic research and clinical settings. Recent studies have highlighted the potential adjuvant role of vitamin D in the treatment of vaginitis while illustrating its role in maintaining microecological balance. Therefore, this study focused on the therapeutic effects of vitamin D on vaginitis.
Methods: The study provided a statistical description of 5978 vaginitis patients who visited Shaanxi Provincial People’s Hospital, presenting data in absolute numbers (%) and mean ± standard deviation (median quartiles were used for non-normally distributed variables). The chi-square test and analysis of variance were employed to analyze the distribution of vitamin D levels among patients, factors influencing vitamin D levels, and the association between recurrence rates and vitamin D levels.
Results: Vitamin D deficiency (57.74%) or insufficiency (22.20%) is prevalent among patients with vaginitis. Furthermore, vitamin D levels have an impact on the dominant bacterial species in the vagina, as well as catalase, acetylglucosaminidase, and the overall vaginal microecological status. Age and BMI have correlations with vitamin D levels. It is hypothesized that this relationship may be attributed to clinicians utilizing vitamin D as a supplementary treatment.
Conclusion: This study examined the statistical findings of vitamin D-related data from 5978 vaginitis patients, revealing a positive correlation between vitamin D deficiency and vaginitis occurrence. Patients with vitamin D deficiency/severe deficiency showed weakly positive levels of catalase and mostly weakly positive levels of acetylglucosaminidase, and most of these vaginitis are trichomonas vaginalis (TV). Furthermore, older individuals and those with higher BMI were found to be more susceptible to symptoms of vitamin D deficiency.

Keywords: Vitamin D, vaginal microecology, female reproductive system diseases