Kelibinuer Mutailipu,1,* Lei Du,2,3,* Junwei Guo,1 Shuwei Liu,1 Yue Chen,1 Liesheng Lu,2 Shen Qu,1 Haibing Chen,1 Le Bu1 

1Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Institute of Obesity, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Department of Metabolic Surgery, Shanghai Tenth People’s Hospital, Institute of Obesity, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 3Department of General Surgery, Chongming Branch, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Le Bu, Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Institute of Obesity, School of Medicine, Tongji University, 301 Yancheng Road, Jin’an District, Shanghai, 200072, People’s Republic of China, Email geyingjun@hotmail.com

Purpose: This study aimed to investigate the association of the triglyceride-glucose index (TyG) and its related parameters with the risk of hyperuricemia in patients with obesity of different sexes.
Patients and Methods: In this cross-sectional study, a total of 951 patients with obesity were included. They were divided into two groups based on their serum uric acid levels, and separate analyses were conducted for males and females. Binary logistic regression analysis using the backward likelihood ratio (LR) approach was performed to investigate the association between hyperuricemia and indicators related to obesity and lipids.
Results: Multivariate logistic regression analysis indicated that, across the overall population, higher quartiles of the TyG and TyG-BMI indexes were significantly associated with an increased risk of hyperuricemia (HUA) after adjusting for confounding factors. Specifically, in the fourth quartile of the TyG index, the odds ratio (OR) for HUA was 3.16 (95% confidence interval [CI]: 1.39– 7.18), and for the TyG-BMI index, the OR was 4.06 (95% CI: 1.73– 9.52) in the fully adjusted model. In sex-specific analyses, for males, those in the third quartile of the TyG-WC index had a higher likelihood of HUA (OR, 8.13; 95% CI, 2.28– 29.01) compared to the lowest quartile. Among females, an elevated TyG index was significantly associated with increased HUA risk, with an OR of 5.13 (95% CI: 1.66– 15.92) in the fourth quartile.
Conclusion: Sex-based differences exist regarding the risk factors for hyperuricemia in patients with obesity. An elevated TyG-WC index is linked to an increased risk in males, while an elevated TyG index is associated with an increased risk in females.

Keywords: Obesity-and lipid-related indexes, triglyceride glucose index, hyperuricemia, obesity