Mengchen Luo,1,* Ting Jin,1,* Yi Fang,1,* Feng Chen,1 Lujian Zhu,2 Jin Bai,3 Jin Ding1 

1Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 2Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China; 3Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Jin Bai, Cancer Institute, Xuzhou Medical University, Xuzhou, People’s Republic of China, Email bj@xzhmu.edu.cn Jin Ding, Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People’s Republic of China, Email jhDingJin@zju.edu.cn

Abstract: Acute pancreatitis (AP) is a common digestive emergency with high morbidity and mortality. Over the past decade, significant progress has been made in understanding the mechanisms of AP, including oxidative stress, disruptions in calcium homeostasis, endoplasmic reticulum stress, inflammatory responses, and various forms of cell death. This review provides an overview of the typical signaling pathways involved and proposes the latest clinical translation prospects. These strategies are important for the early management of AP, preventing multi-organ injury, and improving the overall prognosis of the disease.

Keywords: acute pancreatitis, signaling pathway, calcium overload, endoplasmic reticulum stress, cell death