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美国女性抑郁症严重程度与卵巢癌之间的关联：一项横断面研究
Authors Yang L , Zhang S, Li Y, Qian H, Xu W , Yu J
Received 1 February 2025
Accepted for publication 5 July 2025
Published 18 July 2025 Volume 2025:17 Pages 2145—2155
DOI https://doi.org/10.2147/IJWH.S520260
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Elie Al-Chaer
Li Yang,1,* Shuang Zhang,1,* Yajun Li,2 Haiqing Qian,3 Wenting Xu,3 Jinfen Yu1
1Department of Obstetrics and Gynaecology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People’s Republic of China; 2Department of Orthopedics, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People’s Republic of China; 3Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jinfen Yu, Email zjgzy005@njucm.edu.cn Wenting Xu, Email zjgzyxwt@njucm.edu.cn
Objective: Inflammation is one of the main causes of ovarian cancer. Depression leads to an increase in pro-inflammatory cytokines, which in turn affects the progression and severity of cancer. There is a lack of research on the relationship between depression severity and ovarian cancer. This study aimed to explore the relationship between depression severity and ovarian cancer.
Methods: The study used data from seven cycles of the National Health and Nutrition Examination Survey (NHANES, 2005– 2018). Weighted multivariable logistic regression models were used to analyze the association between depression severity and ovarian cancer.
Results: A total of 14,843 women without cancer and 56 women only with ovarian cancer were included in this study. Weighted multivariable logistic regression models showed that severe depression was associated with ovarian cancer (unadjusted model, OR: 4.94, 95% CI: 1.14, 21.35, p < 0.05, p for trend: 0.1; partially adjusted model, OR: 6.10, 95% CI: 1.35, 27.51, p < 0.05, p for trend: 0.04; fully adjusted model, OR: 5.82, 95% CI: 1.19, 28.52, p < 0.05, p for trend: 0.05).
Conclusion: Severe depression was positively correlated with ovarian cancer. Longitudinal studies are necessary to explore causality.
Keywords: ovarian cancer, depression severity, cross-sectional study, NHANES, PHQ-9