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已发表论文
慢性原发性失眠患者内在的功能连通强度的区域损伤
Authors Huang S, Zhou F, Jiang J, Huang M, Zeng X, Ding S, Gong H
Received 17 March 2017
Accepted for publication 18 April 2017
Published 6 June 2017 Volume 2017:13 Pages 1449—1462
DOI https://doi.org/10.2147/NDT.S137292
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Prof. Dr. Roumen Kirov
Peer reviewer comments 2
Editor who approved publication: Professor Wai Kwong Tang
Abstract: Several neuroimaging
studies have suggested that brain impairment and plasticity occur in patients
with chronic primary insomnia (CPI); however, the effects of insomnia on the
intrinsic organization of the brain remain largely unknown. In this study, a
voxel-based functional connectivity strength (FCS) assessment, a data-driven
method based on a theoretical approach, was applied to investigate the effects
of insomnia on the intrinsic organization of the whole brain in 27
treatment-naïve CPI patients and 26 well-matched healthy controls (HCs).
Compared with HCs, CPI patients exhibited decreased FCS primarily in the right
dorsolateral prefrontal cortex, the right medial prefrontal cortex (MPFC), the
left basal ganglia/insula, and the right cerebellum anterior lobe (CAL) due to
decreased functional connectivity patterns. These results suggest that poor
sleep quality could impair FCS within the brain, including the MPFC and the
CAL, which are important for cognitive control and modulating motor and limbic
functions. Additionally, a receiver operator characteristic analysis revealed
that altered FCS has moderate sensitivity (76.9%–88.5%) and specificity
(59.3%–70.4%) as a reference indicator to discriminate CPI patients from HCs.
Taken together, these findings provide evidence for abnormal intrinsic brain
activity in CPI patients and might improve our understanding of the
pathophysiological processes that occur in insomnia patients.
Keywords: functional connectivity strength, disconnection, chronic primary insomnia, sleep disorders, resting-state fMRI
Keywords: functional connectivity strength, disconnection, chronic primary insomnia, sleep disorders, resting-state fMRI
