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载脂蛋白 A-I 水平与慢性心力衰竭患者的预后相关，尤其是在射血分数中间值心力衰竭和射血分数保留型心力衰竭患者中：一项回顾性队列研究
Authors He X , Li F, Zhang J, Wen Z, Li Y, Gao W, Chen H, Yu Y, Zheng Y, Xie X
Received 29 March 2025
Accepted for publication 13 August 2025
Published 25 August 2025 Volume 2025:18 Pages 4735—4751
DOI https://doi.org/10.2147/IJGM.S531156
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Redoy Ranjan
XueChun He,1,* FaPeng Li,2,* Jian Zhang,1 ZhiYing Wen,1 YanXiao Li,3 WeiTong Gao,1 HongXia Chen,1 YangGuang Yu,1 YingYing Zheng,1 Xiang Xie1
1Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People’s Republic of China; 2Department of Cardiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, People’s Republic of China; 3Department of Cardiology, Zhengzhou University First Affiliated Hospital, Zhengzhou, 450052, People’s Republic of China
*These authors contributed equally to this work
Correspondence: YingYing Zheng, Email zhengying527@163.com Xiang Xie, Email xiangxie999@sina.com
Objective: The present study aimed to explore the predictive value and prognosis of apolipoprotein A-I (ApoA-I) in chronic heart failure (CHF) patients.
Methods: We recruited 4442 patients with CHF who were admitted to The First Affiliated Hospital of Xinjiang University Medical University with a period of ten years from July 2012, and the mean follow-up time was 22.75 months. The endpoints were defined as all-cause mortality (ACM), the patients divided into low and high ApoA-I groups according to the optimal cutoff value of the ROC curve from finally analyzed HF patients.
Results: In the whole follow-up periods, multivariate Cox regression analysis showed that total CHF patients in low ApoA-I groups had significantly increased risk of ACM as compared with patients in the high ApoA-I group (hazard ratio [HR]=0.702, 95%confidence interval [CI]: 0.603– 0.817, P < 0.001). This trend was consistent in patients with heart failure with mid-range (HFmrEF) (HR = 0.443, 95% CI: 0.298– 0.658, P < 0.001) and heart failure with preserved ejection fraction (HFpEF) (HR = 0.704, 95% CI: 0.539– 0.919, P = 0.010), but not in heart failure with reduced ejection fraction (HFrEF) (HR = 0.806, 95% CI: 0.582– 1.116, P = 0.194).
Conclusion: The Apolipoprotein A-I concentrations significantly associated with ACM of CHF especially in HFmrEF and HFpEF.
Keywords: apolipoprotein A-I, chronic heart failure, lipoprotein metabolism, all-cause mortality