108605
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
中国女性黄褐斑皮损的胶带条蛋白质组学分析
Authors Yang Y, Zhao Z, Lu L, Gao N, Hu J, Han G, Ma X
Received 2 May 2025
Accepted for publication 26 August 2025
Published 12 September 2025 Volume 2025:18 Pages 2341—2357
DOI https://doi.org/10.2147/CCID.S538073
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Monica K. Li
Yi Yang,2,* Zheng Zhao,1,* Lulu Lu,1 Na Gao,1 Jiangang Hu,1 Gangwen Han,1 Xiaolei Ma1
1Department of Dermatology, Peking University International Hospital, Beijing, People’s Republic of China; 2Department of Aesthetic and Plastic Surgery, Peking University International Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaolei Ma, Department of Dermatology, Peking University International Hospital, No. 1 Life Park Road, Life Science Park of Zhongguancun, Changping District, Beijing, People’s Republic of China, Email superma.xiaolei@163.com
Purpose: Melasma is a common, chronic, and recurring disorder of hyperpigmentation arising from hyperfunctional melanocytes that deposit excessive amounts of melanin in the epidermis and dermis. The pathophysiology of melasma remains unclear and the treatment is challenging. Proteomic Analysis may contribute to understand the pathogenesis of melasma.
Patients and Methods: In this study, transepidermal water loss(TWEL) was evaluated to assess skin barrier function. Melasma area and severity index score was used to measure the severity of melasma. Data independent acquisition mass spectrometry was used to perform a comparative analysis of protein expression in female skin samples(cheeks) from 8 healthy controls and 8 melasma subjects. The hospital anxiety and depression scale were used to assess the anxiety and depression levels of the melasma patients.
Results: The results showed that the melasma patients had higher TEWL values than the controls (12.95 ± 2.44 versus 6.86 ± 2.19, p < 0.01). Quantitative proteomic analysis identified a total of 230 differentially expressed proteins, including 193 upregulated and 37 downregulated. Enrichment analysis of these proteins based on GO, KEGG databases and protein-protein interaction analysis revealed that functional cluster associated with skin barrier (which included ALB, ANXA5, HSPB1, IQGAP1, S100A7), immunity and inflammation (which included YWHAZ, YWHAE, HSPA5, CSNK2B), melanogenesis (which included ALDH1A1, YWHAH, NDRG2, PMEL, APOE), psychoneurosis (which included YWHAE,YWHAH, PFN1, C3) and hormone (which included ARPC2, HSC70 and HSP70).
Conclusion: Our non-invasive proteomics analysis of human epidermal proteins may guide future research on female melasma and help in the development of treatments for melasma.
Keywords: proteomic, female melasma, Chinese population, tape-strip
1Department of Dermatology, Peking University International Hospital, Beijing, People’s Republic of China; 2Department of Aesthetic and Plastic Surgery, Peking University International Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaolei Ma, Department of Dermatology, Peking University International Hospital, No. 1 Life Park Road, Life Science Park of Zhongguancun, Changping District, Beijing, People’s Republic of China, Email superma.xiaolei@163.com
Purpose: Melasma is a common, chronic, and recurring disorder of hyperpigmentation arising from hyperfunctional melanocytes that deposit excessive amounts of melanin in the epidermis and dermis. The pathophysiology of melasma remains unclear and the treatment is challenging. Proteomic Analysis may contribute to understand the pathogenesis of melasma.
Patients and Methods: In this study, transepidermal water loss(TWEL) was evaluated to assess skin barrier function. Melasma area and severity index score was used to measure the severity of melasma. Data independent acquisition mass spectrometry was used to perform a comparative analysis of protein expression in female skin samples(cheeks) from 8 healthy controls and 8 melasma subjects. The hospital anxiety and depression scale were used to assess the anxiety and depression levels of the melasma patients.
Results: The results showed that the melasma patients had higher TEWL values than the controls (12.95 ± 2.44 versus 6.86 ± 2.19, p < 0.01). Quantitative proteomic analysis identified a total of 230 differentially expressed proteins, including 193 upregulated and 37 downregulated. Enrichment analysis of these proteins based on GO, KEGG databases and protein-protein interaction analysis revealed that functional cluster associated with skin barrier (which included ALB, ANXA5, HSPB1, IQGAP1, S100A7), immunity and inflammation (which included YWHAZ, YWHAE, HSPA5, CSNK2B), melanogenesis (which included ALDH1A1, YWHAH, NDRG2, PMEL, APOE), psychoneurosis (which included YWHAE,YWHAH, PFN1, C3) and hormone (which included ARPC2, HSC70 and HSP70).
Conclusion: Our non-invasive proteomics analysis of human epidermal proteins may guide future research on female melasma and help in the development of treatments for melasma.
Keywords: proteomic, female melasma, Chinese population, tape-strip