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已发表论文
铁氧化物标记的干细胞具有特定磁性特征，可有效应用于顺铂诱导的小鼠急性肾损伤模型
Authors Wang K, Zhao Y, Lv H, Li X
Received 17 March 2025
Accepted for publication 20 August 2025
Published 18 September 2025 Volume 2025:20 Pages 11435—11449
DOI https://doi.org/10.2147/IJN.S528752
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Farooq A. Shiekh
Ke Wang,1,2,* Ye Zhao,3,* Huiying Lv,1 Xiuying Li1
1Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Gynecology and Obstetrics Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 3Dermatological Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiuying Li, Email lixiuying@jlu.edu.cn
Background: Acute kidney injury (AKI) is characterized by the abrupt loss of renal function and lack of curative therapies. Placental-derived mesenchymal stem cells (PL-MSCs) have shown promise in regenerative medicine, including in the treatment of AKI. However, optimizing the therapeutic effects of PL-MSCs remains a critical objective. Magnetic targeting is one potential avenue of optimization. Using iron oxide-labeled MSCs with an external magnetic field to increase cell homing ability may be an ideal method for improving the cell therapy effects in vivo.
Methods: In this study, PL-MSCs were labeled with Fe3O4 nanoparticles coated with polydopamine (Fe3O4@PDA NPs) for 24 h, and cell efficiency and viability were tested. The conditionally immortalized mice renal tubular endothelial cells (mRTECs) were incubated with cisplatin (Cis) and co-cultured with non-labeled or NP-labeled MSCs. The protective effect of NP-labeled MSCs on mRTEC was evaluated. In in vivo experiments, non-labeled or NP-labeled MSCs, with or without an external magnetic field, were injected into mice with Cis-induced AKI. The blood and tissue samples were collected to assess renal function and tissue damage.
Results: The study confirmed that MSCs or MSC-NP can significantly improve Cis-induced mRTEC injury. In addition, NP-labeled MSCs with an external magnetic field (magnetically-targeted MSCs) improved their homing to the kidney tissues in mice with AKI, resulting in enhanced kidney function compared with those of mice treated with MSC or NP-labeled MSC treatment alone. Moreover, magnetically-targeted MSCs alleviated renal injury through suppressing oxidative stress and inflammation, reducing cell apoptosis, and promoting cell proliferation.
Conclusion: Magnetic targeting enhances the therapeutic effects of PL-MSCs on Cis-induced AKI in mice, suggesting that magnetically-targeted MSCs could serve as potential treatments for patients with Cis-induced AKI.
Keywords: acute kidney injury, cisplatin, placental-derived mesenchymal stem cells, inflammation, oxidative stress, apoptosis, proliferation
1Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Gynecology and Obstetrics Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 3Dermatological Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiuying Li, Email lixiuying@jlu.edu.cn
Background: Acute kidney injury (AKI) is characterized by the abrupt loss of renal function and lack of curative therapies. Placental-derived mesenchymal stem cells (PL-MSCs) have shown promise in regenerative medicine, including in the treatment of AKI. However, optimizing the therapeutic effects of PL-MSCs remains a critical objective. Magnetic targeting is one potential avenue of optimization. Using iron oxide-labeled MSCs with an external magnetic field to increase cell homing ability may be an ideal method for improving the cell therapy effects in vivo.
Methods: In this study, PL-MSCs were labeled with Fe3O4 nanoparticles coated with polydopamine (Fe3O4@PDA NPs) for 24 h, and cell efficiency and viability were tested. The conditionally immortalized mice renal tubular endothelial cells (mRTECs) were incubated with cisplatin (Cis) and co-cultured with non-labeled or NP-labeled MSCs. The protective effect of NP-labeled MSCs on mRTEC was evaluated. In in vivo experiments, non-labeled or NP-labeled MSCs, with or without an external magnetic field, were injected into mice with Cis-induced AKI. The blood and tissue samples were collected to assess renal function and tissue damage.
Results: The study confirmed that MSCs or MSC-NP can significantly improve Cis-induced mRTEC injury. In addition, NP-labeled MSCs with an external magnetic field (magnetically-targeted MSCs) improved their homing to the kidney tissues in mice with AKI, resulting in enhanced kidney function compared with those of mice treated with MSC or NP-labeled MSC treatment alone. Moreover, magnetically-targeted MSCs alleviated renal injury through suppressing oxidative stress and inflammation, reducing cell apoptosis, and promoting cell proliferation.
Conclusion: Magnetic targeting enhances the therapeutic effects of PL-MSCs on Cis-induced AKI in mice, suggesting that magnetically-targeted MSCs could serve as potential treatments for patients with Cis-induced AKI.
Keywords: acute kidney injury, cisplatin, placental-derived mesenchymal stem cells, inflammation, oxidative stress, apoptosis, proliferation