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已发表论文
离子导入透明质酸纳米凝胶负载的发酵米提取物可减轻皮肤糖基化
Authors Han Y , Lin Y , Guo M, Wang Y, Dong X, Xiong L, Li L, Wang H, Hu X, Yang F
Received 26 February 2025
Accepted for publication 7 September 2025
Published 18 September 2025 Volume 2025:20 Pages 11417—11434
DOI https://doi.org/10.2147/IJN.S523731
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Xing Zhang
Yuanyuan Han,1,2,* Yunzhi Lin,3,* Miao Guo,4 Yinshu Wang,1,2 Xiuju Dong,1,2 Lidan Xiong,1,2 Li Li,1– 3 Hua Wang,4 Xuefeng Hu,5,6 Fan Yang4
1Evaluation Center for Cosmetics Safety and Efficacy, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Sichuan Engineering Technology Research Center of Cosmetic, Chengdu, Sichuan, People’s Republic of China; 3Department of Dermatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Mageline Biology Tech Co., Ltd, Wuhan, Hubei, People’s Republic of China; 5West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 6Rotex Co., Ltd, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xuefeng Hu, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, No. 17, Section 3, People’s South Road, Chengdu, 610000, People’s Republic of China, Email huxuefeng@scu.edu.cn Fan Yang, Mageline Biology Tech Co, Ltd, Han Street, Wuchang District, Wuhan, Hubei, 430060, People’s Republic of China, Email yangfanfenix@outlook.com
Purpose: This study aims to evaluate the efficacy of Saccharomyces/Rice Ferment Filtrate (SRFF) in mitigating glycation-related skin aging, specifically focusing on the reduction of advanced glycation end products (AGEs) through improved transdermal delivery using nanotechnology and iontophoresis.
Methods: We developed a hyaluronic acid (HA) nanogel as a carrier for SRFF, which enhances drug delivery efficiency and stability while providing skin protection. Iontophoresis, a non-invasive electrochemical method, was employed to facilitate the transdermal penetration of SRFF into the skin. An ex vivo skin tissue glycation model was established, and immunohistochemistry and tissue mechanics assessments were conducted to analyze the effects of SRFF combined with HA nanogel and iontophoresis.
Results: The combination of SRFF with HA nanogel and iontophoresis significantly reduced the formation of AGEs and mitigated the stiffening effects associated with glycation. The results demonstrated pronounced anti-glycation effects at both the cellular and ex vivo tissue levels. The observed reductions in AGEs and improved skin barrier functionality were likely due to the antioxidant properties of SRFF and its ability to competitively bind to AGEs crosslinking sites.
Conclusion: This study highlights the potential of SRFF, in conjunction with HA nanogels and iontophoresis, as an effective method for anti-glycation treatment, reducing AGE accumulation and alleviating skin yellowing and stiffness. The findings support the development of non-invasive, efficacious strategies for enhancing skin health and counteracting the effects of aging.
Keywords: advanced glycation end products, natural inhibitors, non-invasive transdermal, flexible electrodes, mechanical characterization of skin
1Evaluation Center for Cosmetics Safety and Efficacy, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Sichuan Engineering Technology Research Center of Cosmetic, Chengdu, Sichuan, People’s Republic of China; 3Department of Dermatology, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Mageline Biology Tech Co., Ltd, Wuhan, Hubei, People’s Republic of China; 5West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 6Rotex Co., Ltd, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xuefeng Hu, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, No. 17, Section 3, People’s South Road, Chengdu, 610000, People’s Republic of China, Email huxuefeng@scu.edu.cn Fan Yang, Mageline Biology Tech Co, Ltd, Han Street, Wuchang District, Wuhan, Hubei, 430060, People’s Republic of China, Email yangfanfenix@outlook.com
Purpose: This study aims to evaluate the efficacy of Saccharomyces/Rice Ferment Filtrate (SRFF) in mitigating glycation-related skin aging, specifically focusing on the reduction of advanced glycation end products (AGEs) through improved transdermal delivery using nanotechnology and iontophoresis.
Methods: We developed a hyaluronic acid (HA) nanogel as a carrier for SRFF, which enhances drug delivery efficiency and stability while providing skin protection. Iontophoresis, a non-invasive electrochemical method, was employed to facilitate the transdermal penetration of SRFF into the skin. An ex vivo skin tissue glycation model was established, and immunohistochemistry and tissue mechanics assessments were conducted to analyze the effects of SRFF combined with HA nanogel and iontophoresis.
Results: The combination of SRFF with HA nanogel and iontophoresis significantly reduced the formation of AGEs and mitigated the stiffening effects associated with glycation. The results demonstrated pronounced anti-glycation effects at both the cellular and ex vivo tissue levels. The observed reductions in AGEs and improved skin barrier functionality were likely due to the antioxidant properties of SRFF and its ability to competitively bind to AGEs crosslinking sites.
Conclusion: This study highlights the potential of SRFF, in conjunction with HA nanogels and iontophoresis, as an effective method for anti-glycation treatment, reducing AGE accumulation and alleviating skin yellowing and stiffness. The findings support the development of non-invasive, efficacious strategies for enhancing skin health and counteracting the effects of aging.
Keywords: advanced glycation end products, natural inhibitors, non-invasive transdermal, flexible electrodes, mechanical characterization of skin