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已发表论文
基于纳米材料的抗血管生成基因疗法治疗视网膜新生血管疾病：机制见解与临床前进展
Authors Zeng L, Wei Y, Qiu Y, Bi R, Peng H, Hu B, Li Y
Received 11 February 2025
Accepted for publication 8 July 2025
Published 18 September 2025 Volume 2025:20 Pages 11361—11388
DOI https://doi.org/10.2147/IJN.S521960
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Eng San Thian
Longhai Zeng,* Yanhao Wei,* Yanmei Qiu,* Rentang Bi, Haokun Peng, Bo Hu, Ya’nan Li
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ya’nan Li, Email lyn.hust@qq.com Bo Hu, Email hubo@mail.hust.edu.cn
Abstract: Retinal neovascular diseases (RNVs) are the leading cause of preventable vision loss worldwide, including diabetic retinopathy, age related macular degeneration, retinopathy of prematurity, and retinal vein occlusion. Anti-VEGF therapy remains central to current clinical management, while emerging molecular targets, including ANG-2, PDGF, Sema4D, integrins, and inflammatory mediators, are gaining therapeutic relevance. The current standard anti-VEGF intravitreal injection (administered every 4– 8 weeks) regimen significantly increases the risk of complications such as endophthalmitis and elevated intraocular pressure, which has driven interest in one-time gene therapy approaches. However, traditional viral delivery systems for gene therapy are limited by limited drug loading and poor biocompatibility. This review systematically investigated nanomaterial mediated gene therapy options for anti-angiogenesis in RNVs, focusing on six distinct nanomaterial categories: metal nanoparticles, carbon/silicon nanostructures, lipid nanoparticles, polymers, dendrimers, and nanocomposites. The advantages and limitations of various nanomaterials in terms of gene-loading capacity, controlled release profiles, biocompatibility, and transfection efficiency in the preclinical application of anti-angiogenic gene therapy for RNV diseases were compared. It also provides unique insights into the future multi-target therapy of nanomaterials and hybrid nanomaterial delivery.
Keywords: nanomaterials, gene therapy, retinal neovascularization, VEGF
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ya’nan Li, Email lyn.hust@qq.com Bo Hu, Email hubo@mail.hust.edu.cn
Abstract: Retinal neovascular diseases (RNVs) are the leading cause of preventable vision loss worldwide, including diabetic retinopathy, age related macular degeneration, retinopathy of prematurity, and retinal vein occlusion. Anti-VEGF therapy remains central to current clinical management, while emerging molecular targets, including ANG-2, PDGF, Sema4D, integrins, and inflammatory mediators, are gaining therapeutic relevance. The current standard anti-VEGF intravitreal injection (administered every 4– 8 weeks) regimen significantly increases the risk of complications such as endophthalmitis and elevated intraocular pressure, which has driven interest in one-time gene therapy approaches. However, traditional viral delivery systems for gene therapy are limited by limited drug loading and poor biocompatibility. This review systematically investigated nanomaterial mediated gene therapy options for anti-angiogenesis in RNVs, focusing on six distinct nanomaterial categories: metal nanoparticles, carbon/silicon nanostructures, lipid nanoparticles, polymers, dendrimers, and nanocomposites. The advantages and limitations of various nanomaterials in terms of gene-loading capacity, controlled release profiles, biocompatibility, and transfection efficiency in the preclinical application of anti-angiogenic gene therapy for RNV diseases were compared. It also provides unique insights into the future multi-target therapy of nanomaterials and hybrid nanomaterial delivery.
Keywords: nanomaterials, gene therapy, retinal neovascularization, VEGF