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已发表论文
近红外光程控三模态巨噬细胞纳米载体在小鼠模型中的有效抗肿瘤治疗
Authors Xie Y, Shi Y, Li Z, Xu S, Chen Z, Ye X, Yan W
Received 25 May 2025
Accepted for publication 4 September 2025
Published 18 September 2025 Volume 2025:20 Pages 11295—11314
DOI https://doi.org/10.2147/IJN.S542647
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Farooq A. Shiekh
Yiwen Xie,1,* Yuwei Shi,2,* Zhihui Li,2,* Sumei Xu,1 Zhiyun Chen,2 Xuxia Ye,3 Wenxi Yan4
1Department of General Practice, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 2Department of the Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 3School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 4Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenxi Yan, Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 54 Youdian Road, Hangzhou, Zhejiang, 310006, People’s Republic of China, Email yanwenqian123@126.com
Introduction: Chemotherapy remains the primary treatment modality for advanced and unresectable tumors; however, its antitumor efficacy is limited, and it has significant toxic effects on normal tissues.
Methods: To address these challenges, cell carrier- and nanomaterial-based strategies were employed in this study to engineer macrophages into functional “Trojan horses” loaded with ICG–CDDP mesoporous silicon nanoparticles, yielding an intelligent cell carrier chemotherapeutic drug delivery system with controlled light responsiveness and “on-demand” nanophotothermolysis capabilities.
Results: Our findings demonstrate that the intelligent macrophage drug delivery system actively homes to tumor sites and that indocyanine green (ICG) fluorescence can be used to visualize exogenous macrophages at the tumor site. In response irradiation of the delivery area with exogenous near-infrared (NIR) light, ICG generates a thermal effect, resulting in the lysis of macrophages and facilitating spatiotemporally controlled burst release of intracellular cisplatin, thereby precisely targeting tumor cells. Simultaneously, ICG can trigger immunogenic cell death (ICD) under NIR irradiation, transforming “cold tumors” into “hot tumors” and eliciting a prolonged antitumor immune response, thereby overcoming the limitations associated with chemotherapeutic drugs.
Conclusion: This collaborative trimodal strategy successfully represents a triple breakthrough in precise delivery, spatiotemporally controlled drug release, and immune activation. It is an innovative solution for the precise treatment of advanced tumors and has substantial potential for clinical translation.
Keywords: macrophage-mediated drug delivery, spatiotemporally controlled release, immunogenic cell death, ICD, trimodal therapy
1Department of General Practice, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 2Department of the Second Central Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China; 3School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 4Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenxi Yan, Department of Clinical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 54 Youdian Road, Hangzhou, Zhejiang, 310006, People’s Republic of China, Email yanwenqian123@126.com
Introduction: Chemotherapy remains the primary treatment modality for advanced and unresectable tumors; however, its antitumor efficacy is limited, and it has significant toxic effects on normal tissues.
Methods: To address these challenges, cell carrier- and nanomaterial-based strategies were employed in this study to engineer macrophages into functional “Trojan horses” loaded with ICG–CDDP mesoporous silicon nanoparticles, yielding an intelligent cell carrier chemotherapeutic drug delivery system with controlled light responsiveness and “on-demand” nanophotothermolysis capabilities.
Results: Our findings demonstrate that the intelligent macrophage drug delivery system actively homes to tumor sites and that indocyanine green (ICG) fluorescence can be used to visualize exogenous macrophages at the tumor site. In response irradiation of the delivery area with exogenous near-infrared (NIR) light, ICG generates a thermal effect, resulting in the lysis of macrophages and facilitating spatiotemporally controlled burst release of intracellular cisplatin, thereby precisely targeting tumor cells. Simultaneously, ICG can trigger immunogenic cell death (ICD) under NIR irradiation, transforming “cold tumors” into “hot tumors” and eliciting a prolonged antitumor immune response, thereby overcoming the limitations associated with chemotherapeutic drugs.
Conclusion: This collaborative trimodal strategy successfully represents a triple breakthrough in precise delivery, spatiotemporally controlled drug release, and immune activation. It is an innovative solution for the precise treatment of advanced tumors and has substantial potential for clinical translation.
Keywords: macrophage-mediated drug delivery, spatiotemporally controlled release, immunogenic cell death, ICD, trimodal therapy