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已发表论文
纵隔反应性淋巴结肿大淋巴结穿刺液淋巴细胞谱分析及其在鉴别诊断结核性淋巴结炎中的价值
Authors Mi S, Cui N, Wang J, Zhang L, Huang K
Received 23 May 2025
Accepted for publication 2 September 2025
Published 18 September 2025 Volume 2025:18 Pages 4971—4980
DOI https://doi.org/10.2147/IDR.S542415
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hemant Joshi
Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China
Correspondence: Liming Zhang, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86-010-51718892, Tel +86-010-51718892, Email 2378@cyh.com Kewu Huang, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86-010-85231167, Tel +86-010-85231167, Email kewuhuang@126.com
Background: Lymphocyte profile (LP) analysis in mediastinal lymph nodes for differentiating reactive lymphadenopathy (RL) from tuberculous lymphadenitis (TBLA) remains understudied.
Methods: Patients with intrathoracic lymphadenopathy undergoing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) were enrolled. Lymph node puncture fluid (LNPF) was analyzed via flow cytometry to compare LP characteristics between TBLA and RL. Receiver operating characteristic (ROC) analysis identified optimal diagnostic cut-offs, and sensitivity, specificity, and accuracy were calculated.
Results: A total of 41 TBLA cases and 45 RL cases were included. Compared with the TBLA group, the RL group exhibited increased proportions of CD4⁺ T cells and B cells, and decreased proportions of CD8⁺ T cells, natural killer (NK) cells, and natural killer T (NKT) cells in LNPF. Among single parameters, the CD4/CD8 ratio demonstrated the highest diagnostic performance for TBLA, with sensitivity of 88.89%, specificity of 70.73%, and accuracy of 80.23%. Among three-parameter combinations, the CD4⁺ T cell, CD8⁺ T cell, and NK cell ratio combination achieved optimal diagnostic performance, with sensitivity of 80.5%, specificity of 86.7%, and accuracy of 82.6%.
Keywords: tuberculous lymphadenitis, lymphocyte profile, mediastinal lymph node, reactive lymphadenopathy, lymph node puncture fluid
Correspondence: Liming Zhang, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86-010-51718892, Tel +86-010-51718892, Email 2378@cyh.com Kewu Huang, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86-010-85231167, Tel +86-010-85231167, Email kewuhuang@126.com
Background: Lymphocyte profile (LP) analysis in mediastinal lymph nodes for differentiating reactive lymphadenopathy (RL) from tuberculous lymphadenitis (TBLA) remains understudied.
Methods: Patients with intrathoracic lymphadenopathy undergoing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) were enrolled. Lymph node puncture fluid (LNPF) was analyzed via flow cytometry to compare LP characteristics between TBLA and RL. Receiver operating characteristic (ROC) analysis identified optimal diagnostic cut-offs, and sensitivity, specificity, and accuracy were calculated.
Results: A total of 41 TBLA cases and 45 RL cases were included. Compared with the TBLA group, the RL group exhibited increased proportions of CD4⁺ T cells and B cells, and decreased proportions of CD8⁺ T cells, natural killer (NK) cells, and natural killer T (NKT) cells in LNPF. Among single parameters, the CD4/CD8 ratio demonstrated the highest diagnostic performance for TBLA, with sensitivity of 88.89%, specificity of 70.73%, and accuracy of 80.23%. Among three-parameter combinations, the CD4⁺ T cell, CD8⁺ T cell, and NK cell ratio combination achieved optimal diagnostic performance, with sensitivity of 80.5%, specificity of 86.7%, and accuracy of 82.6%.
Keywords: tuberculous lymphadenitis, lymphocyte profile, mediastinal lymph node, reactive lymphadenopathy, lymph node puncture fluid