108552
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
纳米晶天然化合物药物递送系统：进展、挑战与未来机遇
Authors Ji M, Long L, Xiong S, Liu Z, Luo J, Liu D
Received 27 May 2025
Accepted for publication 18 August 2025
Published 17 September 2025 Volume 2025:20 Pages 11315—11339
DOI https://doi.org/10.2147/IJN.S536383
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Jie Huang
Manting Ji,1 Li Long,1 Sijia Xiong,1 Zhongqiu Liu,2 Jun Luo,3 Dan Liu1,3
1Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3Jiangxi Province Key Laboratory of Precision Cell Therapy, The Second Affiliated Hospital of Nanchang University, Nanchang, JIangxi, 330006
Correspondence: Dan Liu; Jun Luo, Email liudan0513@yeah.net; luojun1786@163.com
Abstract: Herbal medicines, under the guidance of Traditional Chinese medicine (TCM) theory, have played an irreplaceable role in treating and controlling various diseases for centuries. However, both traditional and contemporary TCM formulations are plagued by drawbacks such as complex preparation processes, poor stability, and the inconvenience of water decoction. Moreover, natural active ingredients derived from TCM, despite their definite physicochemical properties and significant therapeutic potential—exemplified by the anticancer effects of terpenoids like paclitaxel and tretinoin, and the antihypertensive properties of flavonoids including artemisinin and quercetin—face substantial hurdles in clinical translation due to poor aqueous solubility, low bioavailability, and potential toxicity. Nanocrystalline drug delivery systems (NCDDS) have emerged as a versatile strategy to address these limitations, leveraging the unique properties of nanocrystals to enhance drug dissolution, improve bioavailability, and enable targeted delivery. This review synthesizes recent advancements in NCDDS for natural compounds, elaborating on the current cutting-edge status of preparation techniques and characterization methods, as well as key progress in enhancing the in vitro and in vivo efficacy of natural agents, including terpenoids, flavonoids, and polyphenols. Despite these accomplishments, several challenges persist, such as inadequate colloidal stability, obstacles in scaling up production, and potential long-term toxicity concerns. Future opportunities are centered on the development of advanced nanocrystal preparation technologies, integration with multifunctional modification techniques, and exploration of interdisciplinary cross-applications. The objective of this review is to offer insights into the current landscape of NCDDS for natural compounds and to guide further research efforts toward addressing existing challenges, thereby expediting their clinical translation.
Keywords: herbal medicine, chinese medicine, natural compounds, drug delivery systems, nanocrystal technology
1Department of Pharmacy, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 2Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 3Jiangxi Province Key Laboratory of Precision Cell Therapy, The Second Affiliated Hospital of Nanchang University, Nanchang, JIangxi, 330006
Correspondence: Dan Liu; Jun Luo, Email liudan0513@yeah.net; luojun1786@163.com
Abstract: Herbal medicines, under the guidance of Traditional Chinese medicine (TCM) theory, have played an irreplaceable role in treating and controlling various diseases for centuries. However, both traditional and contemporary TCM formulations are plagued by drawbacks such as complex preparation processes, poor stability, and the inconvenience of water decoction. Moreover, natural active ingredients derived from TCM, despite their definite physicochemical properties and significant therapeutic potential—exemplified by the anticancer effects of terpenoids like paclitaxel and tretinoin, and the antihypertensive properties of flavonoids including artemisinin and quercetin—face substantial hurdles in clinical translation due to poor aqueous solubility, low bioavailability, and potential toxicity. Nanocrystalline drug delivery systems (NCDDS) have emerged as a versatile strategy to address these limitations, leveraging the unique properties of nanocrystals to enhance drug dissolution, improve bioavailability, and enable targeted delivery. This review synthesizes recent advancements in NCDDS for natural compounds, elaborating on the current cutting-edge status of preparation techniques and characterization methods, as well as key progress in enhancing the in vitro and in vivo efficacy of natural agents, including terpenoids, flavonoids, and polyphenols. Despite these accomplishments, several challenges persist, such as inadequate colloidal stability, obstacles in scaling up production, and potential long-term toxicity concerns. Future opportunities are centered on the development of advanced nanocrystal preparation technologies, integration with multifunctional modification techniques, and exploration of interdisciplinary cross-applications. The objective of this review is to offer insights into the current landscape of NCDDS for natural compounds and to guide further research efforts toward addressing existing challenges, thereby expediting their clinical translation.
Keywords: herbal medicine, chinese medicine, natural compounds, drug delivery systems, nanocrystal technology