108552
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
阿尔茨海默病中微胶质细胞知识结构的可视化：基于 CiteSpace 的分析
Authors Wang Q, Zhang X, Wang D, Jiang X, Zhou Y, Zhang T, Yang X, Liu L, Li Q
Received 7 February 2025
Accepted for publication 14 August 2025
Published 17 September 2025 Volume 2025:18 Pages 5917—5933
DOI https://doi.org/10.2147/JMDH.S521350
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Pavani Rangachari
Qi Wang,1 Xiuchu Zhang,2 Delong Wang,3 Xinyu Jiang,2 Yanyan Zhou,1 Te Zhang,4 Xueying Yang,5 Li Liu,6 Quan Li1
1Basic Theory of Traditional Chinese Medicine, College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 3Key Laboratory of Neurobiology of Acupuncture and Moxibustion Clinical Encephalopathy, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150001, People’s Republic of China; 4Department of Fourth Therapy, First Specialized Hospital of Harbin, Harbin, 150000, People’s Republic of China; 5Department of Traditional Chinese Medicine, Harbin First Specialized Hospital, Harbin, 150000, People’s Republic of China; 6Department of Cardiology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, People’s Republic of China
Correspondence: Li Liu, Department of Cardiology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, 26 Heping Road, Xiangfang District, Harbin, 150040, People’s Republic of China, Tel +86 0451-82111401, Email liuli6913@21cn.com Quan Li, Department of Basic Theory of Chinese Medicine, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin, Heilongjiang, 150040, People’s Republic of China, Tel +86 0451-82195947, Tel +86 0451-82195947, Email zyylq78@126.com
Purpose: Alzheimer’s disease (AD) is a growing global health burden, yet effective therapies remain elusive. Microglia—the brain’s resident immune cells—have emerged as key players in AD, capable of both neuroprotection and neurotoxicity. To elucidate research progress and gaps, we conducted a bibliometric analysis of global studies on “microglia and AD” from 2010 to 2025, highlighting advances beyond prior reviews.
Methods: We searched the Web of Science Core Collection for relevant publications (2010– 2025). After screening and deduplication, 12,275 records were analysed with CiteSpace 6.2.R4 to generate co-citation networks, keyword clusters, citation-burst timelines, and collaboration maps at national, institutional, and author levels.
Results: Annual output rose markedly, peaking in 2022. The United States and China led the field; Harvard University, the University of California System, and the Chinese Academy of Sciences were the most prolific institutions. Influential authors included Holtzman, Heneka, Zetterberg, and Colonna. Co-citation analysis revealed three dominant knowledge clusters: microglial activation, TREM2-mediated immune responses, and neuroinflammation. Keyword evolution showed growing attention to TREM2 variants, NLRP3 inflammasome, single-cell omics, and novel imaging techniques, reflecting a shift toward microglial heterogeneity and translational research.
Conclusion: Microglia occupy a central position in AD pathogenesis through intertwined molecular pathways and dynamic functional states. Future work should refine subtype-specific roles, integrate peripheral–central immune interactions, and accelerate the translation of mechanistic insights into targeted interventions. This bibliometric overview maps collaboration patterns and emerging themes, providing a strategic guide for researchers aiming to advance microglia-focused AD therapeutics.
Keywords: microglia, Alzheimer’s disease, neuroinflammation, bibliometric analysis, CiteSpace, collaboration network
1Basic Theory of Traditional Chinese Medicine, College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 3Key Laboratory of Neurobiology of Acupuncture and Moxibustion Clinical Encephalopathy, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150001, People’s Republic of China; 4Department of Fourth Therapy, First Specialized Hospital of Harbin, Harbin, 150000, People’s Republic of China; 5Department of Traditional Chinese Medicine, Harbin First Specialized Hospital, Harbin, 150000, People’s Republic of China; 6Department of Cardiology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, People’s Republic of China
Correspondence: Li Liu, Department of Cardiology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, 26 Heping Road, Xiangfang District, Harbin, 150040, People’s Republic of China, Tel +86 0451-82111401, Email liuli6913@21cn.com Quan Li, Department of Basic Theory of Chinese Medicine, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin, Heilongjiang, 150040, People’s Republic of China, Tel +86 0451-82195947, Tel +86 0451-82195947, Email zyylq78@126.com
Purpose: Alzheimer’s disease (AD) is a growing global health burden, yet effective therapies remain elusive. Microglia—the brain’s resident immune cells—have emerged as key players in AD, capable of both neuroprotection and neurotoxicity. To elucidate research progress and gaps, we conducted a bibliometric analysis of global studies on “microglia and AD” from 2010 to 2025, highlighting advances beyond prior reviews.
Methods: We searched the Web of Science Core Collection for relevant publications (2010– 2025). After screening and deduplication, 12,275 records were analysed with CiteSpace 6.2.R4 to generate co-citation networks, keyword clusters, citation-burst timelines, and collaboration maps at national, institutional, and author levels.
Results: Annual output rose markedly, peaking in 2022. The United States and China led the field; Harvard University, the University of California System, and the Chinese Academy of Sciences were the most prolific institutions. Influential authors included Holtzman, Heneka, Zetterberg, and Colonna. Co-citation analysis revealed three dominant knowledge clusters: microglial activation, TREM2-mediated immune responses, and neuroinflammation. Keyword evolution showed growing attention to TREM2 variants, NLRP3 inflammasome, single-cell omics, and novel imaging techniques, reflecting a shift toward microglial heterogeneity and translational research.
Conclusion: Microglia occupy a central position in AD pathogenesis through intertwined molecular pathways and dynamic functional states. Future work should refine subtype-specific roles, integrate peripheral–central immune interactions, and accelerate the translation of mechanistic insights into targeted interventions. This bibliometric overview maps collaboration patterns and emerging themes, providing a strategic guide for researchers aiming to advance microglia-focused AD therapeutics.
Keywords: microglia, Alzheimer’s disease, neuroinflammation, bibliometric analysis, CiteSpace, collaboration network