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已发表论文
认知与身体双重功能障碍对老年心血管疾病患者长期预后的影响：一项前瞻性队列研究
Authors Liu Y , Chai K, Wang T, Yang Z , Ji L, Guo D, Cui L, Luo Y, Sun N, Wang H
Received 18 April 2025
Accepted for publication 5 September 2025
Published 15 September 2025 Volume 2025:20 Pages 1605—1617
DOI https://doi.org/10.2147/CIA.S535038
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Zhi-Ying Wu
Yujia Liu,1 Ke Chai,2 Ting Wang,1 Zhikai Yang,2 Liwei Ji,3 Di Guo,2 Lingling Cui,2 Yao Luo,2 Ning Sun,2 Hua Wang2
1Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China; 3Department of Pharmacy, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China
Correspondence: Hua Wang, Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1, DaHua Road, Dong Dan, Beijing, 100730, People’s Republic of China, Email wh74220@aliyun.com
Purpose: This study aimed to evaluate the association between physical and cognitive function and long-term outcomes in elderly cardiovascular disease (CVD) patients, using the Short Physical Performance Battery (SPPB) and the Mini-Mental State Examination (MMSE).
Patients and Methods: In this prospective cohort study, 524 patients aged ≥ 65 years hospitalized in the Department of Cardiology at Beijing Hospital from September 2018 to April 2019 were evaluated. Baseline demographic, clinical, laboratory, and functional data were collected, and physical and cognitive function were assessed using SPPB and MMSE scores. Patients were followed for all-cause mortality over a 5-year period. Kaplan-Meier survival analysis and Cox proportional hazards models were used to examine the mortality risk associated with impairments.
Results: Physical impairment was identified in 28.2% and cognitive impairment in 12.4% of patients. The combination of both impairments was associated with a 5.47-fold increased mortality risk (HR: 5.47; 95% CI: 2.78– 10.78; p< 0.001). Each 1-point increase in SPPB and MMSE scores correlated with a 16.3% and 8.7% reduction in mortality risk, respectively. Cognitive function, particularly attention and calculation ability, has emerged as a significant predictor of survival.
Conclusion: Combined physical and cognitive impairments are prevalent in elderly CVD patients and strongly predict poor long-term prognosis. Routine assessment of cognitive function alongside physical performance can improve clinical decision-making, intervention strategies, and patient management, offering the potential to enhance outcomes in this high-risk population.
Keywords: cognitive impairment, physical impairment, cardiovascular disease, all-cause mortality, elderly inpatients
1Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China; 3Department of Pharmacy, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China
Correspondence: Hua Wang, Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1, DaHua Road, Dong Dan, Beijing, 100730, People’s Republic of China, Email wh74220@aliyun.com
Purpose: This study aimed to evaluate the association between physical and cognitive function and long-term outcomes in elderly cardiovascular disease (CVD) patients, using the Short Physical Performance Battery (SPPB) and the Mini-Mental State Examination (MMSE).
Patients and Methods: In this prospective cohort study, 524 patients aged ≥ 65 years hospitalized in the Department of Cardiology at Beijing Hospital from September 2018 to April 2019 were evaluated. Baseline demographic, clinical, laboratory, and functional data were collected, and physical and cognitive function were assessed using SPPB and MMSE scores. Patients were followed for all-cause mortality over a 5-year period. Kaplan-Meier survival analysis and Cox proportional hazards models were used to examine the mortality risk associated with impairments.
Results: Physical impairment was identified in 28.2% and cognitive impairment in 12.4% of patients. The combination of both impairments was associated with a 5.47-fold increased mortality risk (HR: 5.47; 95% CI: 2.78– 10.78; p< 0.001). Each 1-point increase in SPPB and MMSE scores correlated with a 16.3% and 8.7% reduction in mortality risk, respectively. Cognitive function, particularly attention and calculation ability, has emerged as a significant predictor of survival.
Conclusion: Combined physical and cognitive impairments are prevalent in elderly CVD patients and strongly predict poor long-term prognosis. Routine assessment of cognitive function alongside physical performance can improve clinical decision-making, intervention strategies, and patient management, offering the potential to enhance outcomes in this high-risk population.
Keywords: cognitive impairment, physical impairment, cardiovascular disease, all-cause mortality, elderly inpatients