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已发表论文
抗 MDA5 阳性皮肌炎合并类风湿关节炎：一例报告
Authors Yuan F, Huang Z, Zhang E, Yao D, Sun J
Received 28 April 2025
Accepted for publication 28 August 2025
Published 15 September 2025 Volume 2025:18 Pages 2371—2376
DOI https://doi.org/10.2147/CCID.S537273
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Michela Starace
Fuzhen Yuan,1,* Zhenhua Huang,1,2,* Eryao Zhang,1,2 Dingye Yao,1,2 Junsheng Sun1,2
1Department of General Practice, Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, People’s Republic of China; 2Shenzhen Clinical College of Medicine, Guangzhou University of Chinese Medicine, Shenzhen, 518116, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Junsheng Sun, Department of General Practice, Longgang District Central Hospital of Shenzhen, No. 6082, Longgang Avenue, Longgang District, Shenzhen, Guangdong, 518100, People’s Republic of China, Tel +86 0755-28360675, Email junshengsun@126.com
Abstract: We report a rare case of overlap syndrome between anti-MDA5-positive dermatomyositis (DM) and rheumatoid arthritis (RA) in a 65-year-old woman. Initially diagnosed with RA, the patient later developed characteristic DM manifestations including characteristic DM rash, generalized weakness, poor appetite, and unintentional weight loss. Laboratory findings revealed elevated muscle enzymes, positive anti-melanoma differentiation-associated gene 5 (MDA5) antibody and anti-Ro52 antibodies, and increased anti-citrullinated protein antibodies. The patient showed significant improvement following combination therapy with prednisone and mycophenolate mofetil, highlighting the importance of early recognition and appropriate management of this rare overlap syndrome.
Keywords: anti-MDA5 antibodies, dermatomyositis, interstitial lung disease, rheumatoid arthritis, overlap syndrome
1Department of General Practice, Longgang District Central Hospital of Shenzhen, Shenzhen, 518116, People’s Republic of China; 2Shenzhen Clinical College of Medicine, Guangzhou University of Chinese Medicine, Shenzhen, 518116, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Junsheng Sun, Department of General Practice, Longgang District Central Hospital of Shenzhen, No. 6082, Longgang Avenue, Longgang District, Shenzhen, Guangdong, 518100, People’s Republic of China, Tel +86 0755-28360675, Email junshengsun@126.com
Abstract: We report a rare case of overlap syndrome between anti-MDA5-positive dermatomyositis (DM) and rheumatoid arthritis (RA) in a 65-year-old woman. Initially diagnosed with RA, the patient later developed characteristic DM manifestations including characteristic DM rash, generalized weakness, poor appetite, and unintentional weight loss. Laboratory findings revealed elevated muscle enzymes, positive anti-melanoma differentiation-associated gene 5 (MDA5) antibody and anti-Ro52 antibodies, and increased anti-citrullinated protein antibodies. The patient showed significant improvement following combination therapy with prednisone and mycophenolate mofetil, highlighting the importance of early recognition and appropriate management of this rare overlap syndrome.
Keywords: anti-MDA5 antibodies, dermatomyositis, interstitial lung disease, rheumatoid arthritis, overlap syndrome