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已发表论文
高级别胶质瘤术后早期复发的 ADC 值、水肿程度及全身免疫炎症指数的预测价值
Authors Wang M, Wang S, Li Q, Jiang X
Received 11 April 2025
Accepted for publication 27 August 2025
Published 15 September 2025 Volume 2025:18 Pages 12739—12748
DOI https://doi.org/10.2147/JIR.S533915
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Felix Marsh-Wakefield
Man Wang,1 Sisi Wang,2 Qian Li,1 Xili Jiang1
1Center for Radiation Medicine, The Second People’s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, 410007, People’s Republic of China; 2Laboratory Medicine Center, The Second People’s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, 410007, People’s Republic of China
Correspondence: Sisi Wang, Email wangsisi20910@foxmail.com
Background: This study aimed to evaluate the predictive value of apparent diffusion coefficient (ADC) values, degree of edema and the systemic immune-inflammation index (SII) for early postoperative recurrence in high-grade gliomas (HGG).
Methods: This retrospective study analyzed data from patients with HGG who underwent surgery at the Second People’s Hospital of Hunan Province between May 2018 and June 2023. Patients were divided into early recurrence (within six months post-surgery) and non-early recurrence groups. Receiver operating characteristic (ROC) curves were used to develop predictive models for early recurrence of HGG based on ADC, degree of edema and SII.
Results: A total of 68 patients with HGG were included, of whom 20 (29.5%) had early recurrence. Significant differences were observed between the early recurrence and non-early recurrence groups in age, tumor size, degree of edema, and Pathologic grading (all P < 0.05). The area under the ROC curve (AUC) for tumor ADC was 0.623 (95% CI: 0.461– 0.786) with a sensitivity of 0.500 and a specificity of 0.854; for degree of edema, it was 0.652 (95% CI: 0.517– 0.787) with a sensitivity of 0.900 and a specificity of 0.458; and for SII, it was 0.781 (95% CI: 0.663– 0.900) with a sensitivity of 0.750 and a specificity of 0.729. The combined model yielded an AUC of 0.823 (95% CI: 0.715– 0.931) with a sensitivity of 0.800 and a specificity of 0.708.
Conclusion: The combined evaluation of tumor ADC values, SII, and the degree of edema offers predictive value for early recurrence in HGG.
Keywords: ADC value, SII, high grade gliomas, early recurrence, prognosis
1Center for Radiation Medicine, The Second People’s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, 410007, People’s Republic of China; 2Laboratory Medicine Center, The Second People’s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, 410007, People’s Republic of China
Correspondence: Sisi Wang, Email wangsisi20910@foxmail.com
Background: This study aimed to evaluate the predictive value of apparent diffusion coefficient (ADC) values, degree of edema and the systemic immune-inflammation index (SII) for early postoperative recurrence in high-grade gliomas (HGG).
Methods: This retrospective study analyzed data from patients with HGG who underwent surgery at the Second People’s Hospital of Hunan Province between May 2018 and June 2023. Patients were divided into early recurrence (within six months post-surgery) and non-early recurrence groups. Receiver operating characteristic (ROC) curves were used to develop predictive models for early recurrence of HGG based on ADC, degree of edema and SII.
Results: A total of 68 patients with HGG were included, of whom 20 (29.5%) had early recurrence. Significant differences were observed between the early recurrence and non-early recurrence groups in age, tumor size, degree of edema, and Pathologic grading (all P < 0.05). The area under the ROC curve (AUC) for tumor ADC was 0.623 (95% CI: 0.461– 0.786) with a sensitivity of 0.500 and a specificity of 0.854; for degree of edema, it was 0.652 (95% CI: 0.517– 0.787) with a sensitivity of 0.900 and a specificity of 0.458; and for SII, it was 0.781 (95% CI: 0.663– 0.900) with a sensitivity of 0.750 and a specificity of 0.729. The combined model yielded an AUC of 0.823 (95% CI: 0.715– 0.931) with a sensitivity of 0.800 and a specificity of 0.708.
Conclusion: The combined evaluation of tumor ADC values, SII, and the degree of edema offers predictive value for early recurrence in HGG.
Keywords: ADC value, SII, high grade gliomas, early recurrence, prognosis