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已发表论文
氨甲环酸对全膝关节置换术围手术期炎症、长期功能恢复及满意度影响的研究：一项随访研究
Authors Lin S, Zhang X, Xia X, Xu G, Pan H
Received 12 May 2025
Accepted for publication 9 September 2025
Published 15 September 2025 Volume 2025:18 Pages 12769—12781
DOI https://doi.org/10.2147/JIR.S532632
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Justin Jacob
Silong Lin, Xianqi Zhang, Xishang Xia, Guishui Xu, Hong Pan
Orthopedic Surgery, Anqing First People’s Hospital of Anhui Medical University, Anqing, Anhui, People’s Republic of China
Correspondence: Hong Pan, Anqing First People’s Hospital of Anhui Medical University, Anqing, Anhui, People’s Republic of China, Tel +86 18133027706, Email 18133027706@163.com
Purpose: To explore the anti-inflammatory effects and safety of Tranexamic Acid (TXA) during the perioperative period of Total Knee Arthroplasty (TKA) in patients with Knee Osteoarthritis (KOA), and to follow-up on long-term knee joint function and patient satisfaction.
Methods: A prospective non-randomized controlled cohort study evaluated TXA efficacy in 130 unilateral TKA patients with KOA between January 2019 and March 2021. Patients were randomized into TXA (n=65) and control (n=65) groups. The TXA group received both intravenous and intra-articular TXA as required Postoperative coagulation profiles, day-3 systemic inflammatory markers, 6-month DVT/complication rates, and 2-year functional outcomes (knee function, QoL [Quality of Life], satisfaction) were assessed.
Results: No significant differences in demographics, clinical data, or KOA severity were observed between the control and TXA groups (P> 0.05). Only TXA group showed decreased post-operative Fibrinogen (FIB) levels, while Erythrocyte Sedimentation Rate (ESR)(decreased to 15.41 ± 4.39 mm/h), C-reactive Protein (CRP) (decreased to 33.32 ± 11.56 mg/L), and Interleukin 6 (IL-6) levels significantly decreased (decreased to 111.38 ± 30.14 μg/mL) on the third day post-operation (P< 0.001). During the 6 months, specific complications did not significantly differ, but the overall complication rate notably decreased in the TXA group (OR=0.23, 95% CI 0.08 to 0.61, P = 0.012). At 2-year follow-up, TXA group showed significantly better joint function and QoL (P< 0.05). Postoperative satisfaction correlated with preoperative TXA use, neutrophil count, NLR, ESR, and CRP. Multivariate analysis identified TXA as an independent predictor of satisfaction (P< 0.05). TXA group exhibited reduced inflammation, lower complication rates, and improved long-term outcomes, demonstrating favorable perioperative and long-term outcomes in KOA management.
Conclusion: TXA has a significant effect on perioperative inflammation, long-term functional recovery and satisfaction in TKA.
Keywords: total knee arthroplasty, tranexamic acid, observational study, quality of life, inflammatory response
Orthopedic Surgery, Anqing First People’s Hospital of Anhui Medical University, Anqing, Anhui, People’s Republic of China
Correspondence: Hong Pan, Anqing First People’s Hospital of Anhui Medical University, Anqing, Anhui, People’s Republic of China, Tel +86 18133027706, Email 18133027706@163.com
Purpose: To explore the anti-inflammatory effects and safety of Tranexamic Acid (TXA) during the perioperative period of Total Knee Arthroplasty (TKA) in patients with Knee Osteoarthritis (KOA), and to follow-up on long-term knee joint function and patient satisfaction.
Methods: A prospective non-randomized controlled cohort study evaluated TXA efficacy in 130 unilateral TKA patients with KOA between January 2019 and March 2021. Patients were randomized into TXA (n=65) and control (n=65) groups. The TXA group received both intravenous and intra-articular TXA as required Postoperative coagulation profiles, day-3 systemic inflammatory markers, 6-month DVT/complication rates, and 2-year functional outcomes (knee function, QoL [Quality of Life], satisfaction) were assessed.
Results: No significant differences in demographics, clinical data, or KOA severity were observed between the control and TXA groups (P> 0.05). Only TXA group showed decreased post-operative Fibrinogen (FIB) levels, while Erythrocyte Sedimentation Rate (ESR)(decreased to 15.41 ± 4.39 mm/h), C-reactive Protein (CRP) (decreased to 33.32 ± 11.56 mg/L), and Interleukin 6 (IL-6) levels significantly decreased (decreased to 111.38 ± 30.14 μg/mL) on the third day post-operation (P< 0.001). During the 6 months, specific complications did not significantly differ, but the overall complication rate notably decreased in the TXA group (OR=0.23, 95% CI 0.08 to 0.61, P = 0.012). At 2-year follow-up, TXA group showed significantly better joint function and QoL (P< 0.05). Postoperative satisfaction correlated with preoperative TXA use, neutrophil count, NLR, ESR, and CRP. Multivariate analysis identified TXA as an independent predictor of satisfaction (P< 0.05). TXA group exhibited reduced inflammation, lower complication rates, and improved long-term outcomes, demonstrating favorable perioperative and long-term outcomes in KOA management.
Conclusion: TXA has a significant effect on perioperative inflammation, long-term functional recovery and satisfaction in TKA.
Keywords: total knee arthroplasty, tranexamic acid, observational study, quality of life, inflammatory response