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已发表论文
治疗勃起功能障碍的新方法：干细胞来源的细胞外囊泡
Authors Ping X, Zhou H, Zhang Y, Liu X, Tao T, Liu Q, Feng S, Lou K
Received 17 June 2025
Accepted for publication 4 September 2025
Published 13 September 2025 Volume 2025:20 Pages 11249—11266
DOI https://doi.org/10.2147/IJN.S547834
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Kamakhya Misra
Xinglin Ping,1 Haibin Zhou,2 Yumeng Zhang,3 Xiaoliang Liu,3 Tao Tao,1 Qun Liu,4 Shangzhi Feng,2 Kecheng Lou5
1Department of Urology, Jiujiang City Key Laboratory of Cell Therapy, JiuJiang No.1 People’s Hospital, Jiujiang, Jiangxi, People’s Republic of China; 2Department of Urology, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, People’s Republic of China; 3Department of Anesthesiology, Jiujiang College Hospital, Jiujiang, Jiangxi, People’s Republic of China; 4Department of Nursing, Jiujiang College Hospital, Jiujiang, Jiangxi, People’s Republic of China; 5Department of Urology, Lanxi People’s Hospital, Jinhua, Zhejiang, People’s Republic of China
Correspondence: Shangzhi Feng, Email 1131718266@qq.com Kecheng Lou, Email 18329037615@163.com
Abstract: Erectile dysfunction refers to the inability of men to achieve or maintain sufficient erection during sexual activity, which significantly impacts their quality of life and mental health. The causes of erectile dysfunction are complex, involving multiple systems such as vascular, neural, endocrine, and psychological factors. Current treatment methods for erectile dysfunction have significant limitations in addressing organic lesions, particularly penile fibrosis and hypoxic microenvironments. However, the latest stem cell-derived nanovesicle technology has been found to significantly reverse cellular fibrosis and alter the cellular microenvironment, potentially offering a new therapeutic approach for erectile dysfunction. Additionally, extracellular vesicles derived from stem cells can exert stem cell-like regenerative effects while overcoming challenges associated with cell therapy, making them excellent tools for regenerative repair. Therefore, this paper summarizes the potential of extracellular vesicles from different stem cell sources in the treatment of erectile dysfunction and analyzes their engineered preclinical studies to facilitate their translation from the laboratory to clinical applications.
Keywords: erectile dysfunction, stem cells, stem cell-derived extracellular vesicles, regenerative medicine, nanomedicine
1Department of Urology, Jiujiang City Key Laboratory of Cell Therapy, JiuJiang No.1 People’s Hospital, Jiujiang, Jiangxi, People’s Republic of China; 2Department of Urology, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, People’s Republic of China; 3Department of Anesthesiology, Jiujiang College Hospital, Jiujiang, Jiangxi, People’s Republic of China; 4Department of Nursing, Jiujiang College Hospital, Jiujiang, Jiangxi, People’s Republic of China; 5Department of Urology, Lanxi People’s Hospital, Jinhua, Zhejiang, People’s Republic of China
Correspondence: Shangzhi Feng, Email 1131718266@qq.com Kecheng Lou, Email 18329037615@163.com
Abstract: Erectile dysfunction refers to the inability of men to achieve or maintain sufficient erection during sexual activity, which significantly impacts their quality of life and mental health. The causes of erectile dysfunction are complex, involving multiple systems such as vascular, neural, endocrine, and psychological factors. Current treatment methods for erectile dysfunction have significant limitations in addressing organic lesions, particularly penile fibrosis and hypoxic microenvironments. However, the latest stem cell-derived nanovesicle technology has been found to significantly reverse cellular fibrosis and alter the cellular microenvironment, potentially offering a new therapeutic approach for erectile dysfunction. Additionally, extracellular vesicles derived from stem cells can exert stem cell-like regenerative effects while overcoming challenges associated with cell therapy, making them excellent tools for regenerative repair. Therefore, this paper summarizes the potential of extracellular vesicles from different stem cell sources in the treatment of erectile dysfunction and analyzes their engineered preclinical studies to facilitate their translation from the laboratory to clinical applications.
Keywords: erectile dysfunction, stem cells, stem cell-derived extracellular vesicles, regenerative medicine, nanomedicine