108552
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
艾氯胺酮在老年患者围手术期的临床益处与挑战
Authors Zhang S , Bai C , Xu M, Li Y, Han Y, Jin Y , Zhao X
Received 30 April 2025
Accepted for publication 2 September 2025
Published 13 September 2025 Volume 2025:19 Pages 8251—8263
DOI https://doi.org/10.2147/DDDT.S536813
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Tuo Deng
Shuai Zhang,1 Chen Bai,1 Mingcan Xu,1 Yiqing Li,1 Ying Han,1 Yanwu Jin,1,2 Xin Zhao1
1Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Anesthesiology, Public Health Clinical Center, Shandong University, Jinan, People’s Republic of China
Correspondence: Yanwu Jin; Xin Zhao, Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China, Email jinyanwu_aa@163.com; lujnzx@sohu.com
Abstract: Ketamine is a classic intravenous anesthetic. Esketamine is a dextro-isomer of ketamine, with similar mechanism of action, mainly through non-competitive antagonism of N-methyl-D-aspartate receptors, higher potency and fewer adverse effects. The characteristics of esketamine include circulatory stimulation, bronchodilatation, inhibition of inflammation and dissociative anesthetic properties. Esketamine was approved for clinical practice in China in 2019, and has significant advantages for use in pediatric, maternal, elderly or shock patients. The clinical use of esketamine is currently receiving widespread attention. This article reviews the recent progress and limitations of clinical studies on the perioperative use of esketamine in elderly patients, covering its pharmacological properties, hemodynamic effects, analgesic benefits, and impacts on depression, sleep, and neurocognitive function, to provide theoretical reference for its application in anesthesia and offer dosage recommendations for elderly patients.
Keywords: esketamine, elderly patients, clinical application, perioperative period
1Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Anesthesiology, Public Health Clinical Center, Shandong University, Jinan, People’s Republic of China
Correspondence: Yanwu Jin; Xin Zhao, Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China, Email jinyanwu_aa@163.com; lujnzx@sohu.com
Abstract: Ketamine is a classic intravenous anesthetic. Esketamine is a dextro-isomer of ketamine, with similar mechanism of action, mainly through non-competitive antagonism of N-methyl-D-aspartate receptors, higher potency and fewer adverse effects. The characteristics of esketamine include circulatory stimulation, bronchodilatation, inhibition of inflammation and dissociative anesthetic properties. Esketamine was approved for clinical practice in China in 2019, and has significant advantages for use in pediatric, maternal, elderly or shock patients. The clinical use of esketamine is currently receiving widespread attention. This article reviews the recent progress and limitations of clinical studies on the perioperative use of esketamine in elderly patients, covering its pharmacological properties, hemodynamic effects, analgesic benefits, and impacts on depression, sleep, and neurocognitive function, to provide theoretical reference for its application in anesthesia and offer dosage recommendations for elderly patients.
Keywords: esketamine, elderly patients, clinical application, perioperative period