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已发表论文
皮肤中的细胞外囊泡：生物学功能与治疗潜力
Authors Yuan S , Jin M , Zhang Y, Zhang M, Yuan M, Ding X, Wang J
Received 23 June 2025
Accepted for publication 4 September 2025
Published 13 September 2025 Volume 2025:20 Pages 11211—11233
DOI https://doi.org/10.2147/IJN.S548986
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Kamakhya Misra
Siqi Yuan,1– 3 Mengyu Jin,1– 3 Yanyan Zhang,1– 3 Mengting Zhang,4 Minjia Yuan,5 Xiaolei Ding,1– 3 Juan Wang1– 3
1Institute of Geriatrics, Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong, Jiangsu, People’s Republic of China; 2Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, People’s Republic of China; 3Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, People’s Republic of China; 4School of Pharmacy, Fudan University, Shanghai, People’s Republic of China; 5Shanghai Qiran Biotechnology Co., Ltd, Shanghai, People’s Republic of China
Correspondence: Xiaolei Ding; Juan Wang, Email xlding@shu.edu.cn; Juanw@shu.edu.cn
Abstract: Extracellular vesicles (EVs) are nanoscale, lipid bilayer-enclosed particles containing bioactive molecules that play crucial roles in tissue homeostasis. These vesicles regulate cellular functions via delivery of protein, lipid, and nucleic acid cargos to target cells, thereby orchestrating essential biological processes, including cellular proliferation, activation, angiogenesis, and immune responses. The past decade has witnessed unprecedented growth in research examining EV functions in cutaneous physiology and pathogenesis. Here, we describe the biogenesis, composition and cellular uptake of EVs, critically highlighting the therapeutic effects and potential mechanisms of EVs from mammalian, plant and bacterial cells in skin diseases, including skin wound healing, hair growth, aging, inflammatory diseases and cancers. In addition, we discuss clinical translation challenges and outline future research directions for advancing EV-based therapeutics in clinical dermatology.
Keywords: extracellular vesicles, wound healing, hair growth, aging, inflammatory skin diseases, skin cancer
1Institute of Geriatrics, Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong, Jiangsu, People’s Republic of China; 2Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, People’s Republic of China; 3Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, People’s Republic of China; 4School of Pharmacy, Fudan University, Shanghai, People’s Republic of China; 5Shanghai Qiran Biotechnology Co., Ltd, Shanghai, People’s Republic of China
Correspondence: Xiaolei Ding; Juan Wang, Email xlding@shu.edu.cn; Juanw@shu.edu.cn
Abstract: Extracellular vesicles (EVs) are nanoscale, lipid bilayer-enclosed particles containing bioactive molecules that play crucial roles in tissue homeostasis. These vesicles regulate cellular functions via delivery of protein, lipid, and nucleic acid cargos to target cells, thereby orchestrating essential biological processes, including cellular proliferation, activation, angiogenesis, and immune responses. The past decade has witnessed unprecedented growth in research examining EV functions in cutaneous physiology and pathogenesis. Here, we describe the biogenesis, composition and cellular uptake of EVs, critically highlighting the therapeutic effects and potential mechanisms of EVs from mammalian, plant and bacterial cells in skin diseases, including skin wound healing, hair growth, aging, inflammatory diseases and cancers. In addition, we discuss clinical translation challenges and outline future research directions for advancing EV-based therapeutics in clinical dermatology.
Keywords: extracellular vesicles, wound healing, hair growth, aging, inflammatory skin diseases, skin cancer