108605
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
左束支区域起搏改善了依赖起搏器患者的左心房结局：一项使用斑点追踪和三维超声心动图的前瞻性队列研究
Authors Mei Y, Han R, Cheng L, Wang Z, He Y, Liu W, Wu Y
Received 7 September 2024
Accepted for publication 14 January 2025
Published 13 September 2025 Volume 2025:21 Pages 1343—1358
DOI https://doi.org/10.2147/TCRM.S481237
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor De Yun Wang
Yingchen Mei,1 Rui Han,1,2 Liting Cheng,3 Zefeng Wang,2 Yihua He,4 Wei Liu,1 Yongquan Wu2
1Department of Cardiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Cardiac Pacing and CIED Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3School of Medicine, Nankai University, Tianjin, People’s Republic of China; 4Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China
Correspondence: Wei Liu, Department of Cardiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, People’s Republic of China, Tel +86 18910938225, Email liuwei525@hotmail.com Yongquan Wu, Cardiac Pacing and CIED Center, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing, 100029, People’s Republic of China, Tel +86 13810751596, Email wuyongquan67@163.com
Purpose: Evidence that left bundle branch area pacing (LBBAP) is more effective than conventional right ventricular (RV) pacing in enhancing left atrial (LA) outcomes is lacking. The aim of this study was to investigate LA outcomes using 2-dimensional speckle tracking echocardiography (2D-STE) and real-time 3-dimensional echocardiography (RT-3DE) at 6-months of follow-up in patients that received LBBAP, RV septal pacing (RVSP), or RV apical pacing (RVAP).
Methods: A total of 90 patients with normal left ventricular ejection fraction (LVEF) underwent dual-chamber pacemaker implantation for bradycardia at Beijing Anzhen Hospital between January 2021 and July 2021. Patients were divided into three groups based on the pacing site: LBBAP, RVSP, or RVAP.
Results: There were no significant differences in baseline characteristics and echocardiographic findings among patients that received LBBAP, RVSP, or RVAP. At 6-months of follow-up, left atrial volume index (LAVI), LA reservoir strain (LASr), LA contractile strain (LASct), global longitudinal strain (GLS), global circumferential strain (GCS), and synchronization parameters (Tmsv-16SD, Tmsv-12SD, Tmsv-6SD, longitudinal Tϵ-dif, circumferential Tϵ-dif) were significantly improved in patients that received LBBAP, while they had significantly worsened with RVSP and RVAP. Compared to baseline, at 6-months of follow-up, patients that received LBBAP had significantly improved LASr (28.17± 10.12% vs 35.4± 17.17%, P=0.024), LASct (− 12.03± 2.15% vs − 17.53± 7.37%, P=0.045), E/e’ ratio(12.61± 3.8 vs 10.85± 3.75,P=0.014) and LVEF (65.74± 7.90% vs 68.81± 5.92%, P=0.023). The 6-minute walking distance significantly increased at 6-months of follow-up compared to baseline in all patients, but the increase was most prominent for LBBAP (403.00± 98.46 m vs. 469.34± 59.32m, P=0.015). LBBAP was associated with a lower risk of new-onset atrial fibrillation.
Conclusion: In pacemaker-dependent patients, LBBAP achieved better LA strain, LV strain, and LV synchronization than RVSP or RVAP at 6-months of follow-up.
Plain Language Summary: This registered prospective study (ChiCTR2100048503) used two-dimensional speckle tracking echocardiography (STE) and real-time 3D echocardiography (RT-3DE) to comprehensively evaluate LA and LV function and mechanical synchrony in LBBAP. This study demonstrates that LBBAP can achieve better LA strain, LV strain and LV synchronization than RVSP or RVAP at 6-months of follow-up.
Keywords: left atrial, left ventricular, mechanical synchrony, left bundle branch area pacing, real-time 3-dimensional echocardiography, speckle tracking echocardiography
1Department of Cardiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Cardiac Pacing and CIED Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3School of Medicine, Nankai University, Tianjin, People’s Republic of China; 4Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China
Correspondence: Wei Liu, Department of Cardiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, People’s Republic of China, Tel +86 18910938225, Email liuwei525@hotmail.com Yongquan Wu, Cardiac Pacing and CIED Center, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing, 100029, People’s Republic of China, Tel +86 13810751596, Email wuyongquan67@163.com
Purpose: Evidence that left bundle branch area pacing (LBBAP) is more effective than conventional right ventricular (RV) pacing in enhancing left atrial (LA) outcomes is lacking. The aim of this study was to investigate LA outcomes using 2-dimensional speckle tracking echocardiography (2D-STE) and real-time 3-dimensional echocardiography (RT-3DE) at 6-months of follow-up in patients that received LBBAP, RV septal pacing (RVSP), or RV apical pacing (RVAP).
Methods: A total of 90 patients with normal left ventricular ejection fraction (LVEF) underwent dual-chamber pacemaker implantation for bradycardia at Beijing Anzhen Hospital between January 2021 and July 2021. Patients were divided into three groups based on the pacing site: LBBAP, RVSP, or RVAP.
Results: There were no significant differences in baseline characteristics and echocardiographic findings among patients that received LBBAP, RVSP, or RVAP. At 6-months of follow-up, left atrial volume index (LAVI), LA reservoir strain (LASr), LA contractile strain (LASct), global longitudinal strain (GLS), global circumferential strain (GCS), and synchronization parameters (Tmsv-16SD, Tmsv-12SD, Tmsv-6SD, longitudinal Tϵ-dif, circumferential Tϵ-dif) were significantly improved in patients that received LBBAP, while they had significantly worsened with RVSP and RVAP. Compared to baseline, at 6-months of follow-up, patients that received LBBAP had significantly improved LASr (28.17± 10.12% vs 35.4± 17.17%, P=0.024), LASct (− 12.03± 2.15% vs − 17.53± 7.37%, P=0.045), E/e’ ratio(12.61± 3.8 vs 10.85± 3.75,P=0.014) and LVEF (65.74± 7.90% vs 68.81± 5.92%, P=0.023). The 6-minute walking distance significantly increased at 6-months of follow-up compared to baseline in all patients, but the increase was most prominent for LBBAP (403.00± 98.46 m vs. 469.34± 59.32m, P=0.015). LBBAP was associated with a lower risk of new-onset atrial fibrillation.
Conclusion: In pacemaker-dependent patients, LBBAP achieved better LA strain, LV strain, and LV synchronization than RVSP or RVAP at 6-months of follow-up.
Plain Language Summary: This registered prospective study (ChiCTR2100048503) used two-dimensional speckle tracking echocardiography (STE) and real-time 3D echocardiography (RT-3DE) to comprehensively evaluate LA and LV function and mechanical synchrony in LBBAP. This study demonstrates that LBBAP can achieve better LA strain, LV strain and LV synchronization than RVSP or RVAP at 6-months of follow-up.
Keywords: left atrial, left ventricular, mechanical synchrony, left bundle branch area pacing, real-time 3-dimensional echocardiography, speckle tracking echocardiography