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已发表论文
磁性微粒化学发光技术在广州患者致敏检测中的应用：基于真实世界医疗数据的研究
Authors Huang H, Chen Y, Hu H, Zheng P , Luo W, Fang Y, Lin Y, Sun B
Received 12 May 2025
Accepted for publication 21 August 2025
Published 12 September 2025 Volume 2025:18 Pages 1255—1267
DOI https://doi.org/10.2147/JAA.S534408
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Amrita Dosanjh
Huimin Huang,1,2,* Yifan Chen,1,* Haisheng Hu,1 Peiyan Zheng,1 Wenting Luo,1 Yanting Fang,1 Yinghong Lin,1 Baoqing Sun1,2
1Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Guangzhou National Laboratory, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Baoqing Sun, Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 28 Qiaozhongzhong road, Guangzhou, People’s Republic of China, Email sunbaoqing@vip.163.com
Objective: Magnetic particle chemiluminescence is a novel allergen detection technology recently introduced in clinical practice in China. This study analyzed the application of the ALLEOS assay using real-world clinical data from Guangzhou to identify regional allergen sensitization patterns.
Methods: A retrospective review of 20,406 suspected allergy patients, tested for 28 specific allergens using the ALLEOS 2000 system at the First Affiliated Hospital of Guangzhou Medical University from June 2021 to January 2024.
Results: The highest positive rate was observed for Dermatophagoides farinae (53.4%), followed by D. pteronyssinus (43.2%) and tropical mites (20.4%). Children showed significantly higher positivity rates for most allergens compared to adults, except for dog dander and German cockroach (P < 0.05). Among allergic diseases, children predominated in rhinitis (84.9%), while adults predominated in asthma (56.5%). In terms of severity, asthma and rhinitis patients exhibited higher sensitization levels (Class 3– 6) to D. pteronyssinus (81.6% and 86.3%) and D. farinae (86.7% and 87.3%), while dermatitis patients were more sensitized to egg (19.7%) and milk (17.9%) allergens. Allergen positivity rates varied by season, with children showing significantly higher sensitization to both daisy and dandelion in autumn (11.1% and 8.8%) and winter (11.8% and 16.7%). In childhood (ages 0– 4), egg (31.4%) and milk (27.1%) sensitization rates peaked and declined with age, whereas animal dander showed lower rates (< 10.0%). Multiple sensitizations were observed in 22.2% of patients. Analysis of sensitization patterns revealed three main categories for inhalation allergens: mite-dominant, animal dander-dominant, and pollen-dominant sensitizations, with a Cronbach’s α of 0.889. Similarly, food allergies were categorized into egg and milk-dominant, nut-dominant, and seafood-dominant patterns, with a Cronbach’s α of 0.932.
Conclusion: This real-world study revealed age-, disease-, and season-specific allergen sensitization patterns in southern China. Inhalant and food allergens formed three major sensitization clusters each. These findings support region- and population-specific testing strategies and may inform clinical decision-making.
Keywords: allergen, sIgE, magnetic particle chemiluminescence, diagnostic technology, real-world study
1Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Guangzhou National Laboratory, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Baoqing Sun, Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 28 Qiaozhongzhong road, Guangzhou, People’s Republic of China, Email sunbaoqing@vip.163.com
Objective: Magnetic particle chemiluminescence is a novel allergen detection technology recently introduced in clinical practice in China. This study analyzed the application of the ALLEOS assay using real-world clinical data from Guangzhou to identify regional allergen sensitization patterns.
Methods: A retrospective review of 20,406 suspected allergy patients, tested for 28 specific allergens using the ALLEOS 2000 system at the First Affiliated Hospital of Guangzhou Medical University from June 2021 to January 2024.
Results: The highest positive rate was observed for Dermatophagoides farinae (53.4%), followed by D. pteronyssinus (43.2%) and tropical mites (20.4%). Children showed significantly higher positivity rates for most allergens compared to adults, except for dog dander and German cockroach (P < 0.05). Among allergic diseases, children predominated in rhinitis (84.9%), while adults predominated in asthma (56.5%). In terms of severity, asthma and rhinitis patients exhibited higher sensitization levels (Class 3– 6) to D. pteronyssinus (81.6% and 86.3%) and D. farinae (86.7% and 87.3%), while dermatitis patients were more sensitized to egg (19.7%) and milk (17.9%) allergens. Allergen positivity rates varied by season, with children showing significantly higher sensitization to both daisy and dandelion in autumn (11.1% and 8.8%) and winter (11.8% and 16.7%). In childhood (ages 0– 4), egg (31.4%) and milk (27.1%) sensitization rates peaked and declined with age, whereas animal dander showed lower rates (< 10.0%). Multiple sensitizations were observed in 22.2% of patients. Analysis of sensitization patterns revealed three main categories for inhalation allergens: mite-dominant, animal dander-dominant, and pollen-dominant sensitizations, with a Cronbach’s α of 0.889. Similarly, food allergies were categorized into egg and milk-dominant, nut-dominant, and seafood-dominant patterns, with a Cronbach’s α of 0.932.
Conclusion: This real-world study revealed age-, disease-, and season-specific allergen sensitization patterns in southern China. Inhalant and food allergens formed three major sensitization clusters each. These findings support region- and population-specific testing strategies and may inform clinical decision-making.
Keywords: allergen, sIgE, magnetic particle chemiluminescence, diagnostic technology, real-world study