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已发表论文
具有增强抗菌活性的用于伤口愈合应用的 BPEI 稳定型光催化金/二氧化钛纳米团簇
Authors Ke J, Jiang L, Sun Q, Wu S, Zheng H, Ye J, Zheng H, Zhong Y, Huang D, Wu Y, Wang B , Weng Z
Received 5 February 2025
Accepted for publication 26 July 2025
Published 12 September 2025 Volume 2025:20 Pages 11197—11210
DOI https://doi.org/10.2147/IJN.S520784
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Krishna Nune
Junheng Ke,1,2,* Linhai Jiang,1,3,* Qi Sun,2 Sifang Wu,2 Houbing Zheng,1,3 Jialin Ye,2 Haisu Zheng,2 Yi Zhong,2 Da Huang,2 Yuanzi Wu,2 Biao Wang,1,3 Zuquan Weng1,2
1Department of Plastic and Cosmetic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, People’s Republic of China; 3Department of Plastic and Cosmetic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Biao Wang, Email 1812166371@qq.com Zuquan Weng, Email wengzq@fzu.edu.cn
Introduction: Wound healing requires dressings with bactericidal effects, where photocatalysis utilizes solar energy to generate reactive oxygen species (ROS) for microbial inactivation. However, most photocatalysts depend on non-visible light, hindering solar-driven therapies. This study developed visible light-responsive Au/Titania/BPEI (TAB) nanoclusters embedded in PDMS, offering enhanced stability, antimicrobial efficacy, and resistance-free antibacterial action.
Methods: TAB composites were synthesized as photocatalytic dressings, with Au nanoclusters enhancing visible-light activity. Characterization included XPS, BET, FTIR, XRD, SEM/TEM, and reflectance spectroscopy. Antibacterial performance was evaluated against pathogens under visible light (0– 150 mW/cm²) using in vitro (3T3 cytotoxicity) and in vivo murine models, with ROS mechanisms analyzed.
Results: TA composites achieved 80% bacterial inhibition within 30 minutes of visible light exposure, attributed to ROS generation that disrupts bacterial DNA, membranes, and proteins. BPEI integration enhanced photocatalytic stability by reducing Aux aggregation and sustaining efficacy across light intensities (20– 150 mW/cm²) with retained activity (> 70% inhibition) even at saturation thresholds. In vivo models demonstrated reduced pro-inflammatory responses and accelerated healing, while 3T3 assays confirmed high biocompatibility (cell viability > 90%).
Discussion: This visible light-activated system provides a resistance-free antibacterial alternative to antibiotics and alcohol-based disinfectants. While TA composites effectively address bacterial infections, limitations include residual bacteria (20% survival) and untested efficacy against fungi/viruses. Future work will optimize material performance for near-complete pathogen eradication and integrate biosensors for real-time infection monitoring. The adaptability of our platform to diverse light environments (sunlight to indoor lighting) and ROS-driven mechanism highlights its potential for clinical translation in combating multidrug-resistant infections.
Keywords: photocatalysis, Au nanocluster, titanium dioxide, wound disinfection
1Department of Plastic and Cosmetic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian, People’s Republic of China; 3Department of Plastic and Cosmetic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Biao Wang, Email 1812166371@qq.com Zuquan Weng, Email wengzq@fzu.edu.cn
Introduction: Wound healing requires dressings with bactericidal effects, where photocatalysis utilizes solar energy to generate reactive oxygen species (ROS) for microbial inactivation. However, most photocatalysts depend on non-visible light, hindering solar-driven therapies. This study developed visible light-responsive Au/Titania/BPEI (TAB) nanoclusters embedded in PDMS, offering enhanced stability, antimicrobial efficacy, and resistance-free antibacterial action.
Methods: TAB composites were synthesized as photocatalytic dressings, with Au nanoclusters enhancing visible-light activity. Characterization included XPS, BET, FTIR, XRD, SEM/TEM, and reflectance spectroscopy. Antibacterial performance was evaluated against pathogens under visible light (0– 150 mW/cm²) using in vitro (3T3 cytotoxicity) and in vivo murine models, with ROS mechanisms analyzed.
Results: TA composites achieved 80% bacterial inhibition within 30 minutes of visible light exposure, attributed to ROS generation that disrupts bacterial DNA, membranes, and proteins. BPEI integration enhanced photocatalytic stability by reducing Aux aggregation and sustaining efficacy across light intensities (20– 150 mW/cm²) with retained activity (> 70% inhibition) even at saturation thresholds. In vivo models demonstrated reduced pro-inflammatory responses and accelerated healing, while 3T3 assays confirmed high biocompatibility (cell viability > 90%).
Discussion: This visible light-activated system provides a resistance-free antibacterial alternative to antibiotics and alcohol-based disinfectants. While TA composites effectively address bacterial infections, limitations include residual bacteria (20% survival) and untested efficacy against fungi/viruses. Future work will optimize material performance for near-complete pathogen eradication and integrate biosensors for real-time infection monitoring. The adaptability of our platform to diverse light environments (sunlight to indoor lighting) and ROS-driven mechanism highlights its potential for clinical translation in combating multidrug-resistant infections.
Keywords: photocatalysis, Au nanocluster, titanium dioxide, wound disinfection