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已发表论文
肥胖与衰老在骨关节炎发病机制中的双向作用：分子机制、表观遗传学见解及治疗意义
Authors Lin C, Yang J, Su H, Zhang X, Wang B
Received 18 January 2025
Accepted for publication 19 July 2025
Published 12 September 2025 Volume 2025:18 Pages 12637—12676
DOI https://doi.org/10.2147/JIR.S514521
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Tara Strutt
Chuang Lin,1 Junxing Yang,1 Hang Su,2 Xinguo Zhang,1 Bo Wang3
1Department of Bone Injury, Shenzhen Hospital, Guangzhou University of Chinese Medicine (Futian), Shenzhen, 518000, People’s Republic of China; 2Department of Medicine, Guangzhou University of Chinese Medicine Shenzhen Hospital (Futian), Shenzhen, 518000, People’s Republic of China; 3Department of Bone Injury, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150036, People’s Republic of China
Correspondence: Bo Wang, Department of Bone Injury, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150036, People’s Republic of China, Tel +86-18646246661, Email wb8788000@163.com
Abstract: Osteoarthritis (OA) is a major global contributor to pain, disability, and socioeconomic burden. With the increasing prevalence of obesity and an aging population, the incidence of OA continues to rise. This review explores the bidirectional relationship between obesity and aging in the pathogenesis of OA, focusing on the underlying molecular mechanisms. Obesity contributes to aging by inducing oxidative stress, chronic inflammation, and metabolic dysregulation, thereby promoting OA development and progression. Conversely, the accumulation of senescent cells with age exacerbates obesity-induced inflammation and metabolic dysfunction by secreting pro-inflammatory cytokines and bioactive molecules. Epigenetic changes, including DNA methylation, histone modifications, and the regulation of non-coding RNAs, play pivotal roles in modulating these interactions, further influencing OA progression. The review also discusses current and emerging therapeutic strategies targeting the obesity-aging-OA axis, highlighting the potential of epigenetic interventions and novel anti-inflammatory treatments. A comprehensive understanding of the molecular interplay between obesity and aging in OA is essential for developing more effective prevention and treatment strategies. Future research should prioritize the in-depth exploration of epigenetic mechanisms, coupled with technological innovation, standardized education and training, quality control, and multidisciplinary collaboration. Targeted strategies and interventions are essential to effectively prevent and manage obesity- and OA-related diseases.
Keywords: obesity, aging, osteoarthritis, epigenetics, inflammation
1Department of Bone Injury, Shenzhen Hospital, Guangzhou University of Chinese Medicine (Futian), Shenzhen, 518000, People’s Republic of China; 2Department of Medicine, Guangzhou University of Chinese Medicine Shenzhen Hospital (Futian), Shenzhen, 518000, People’s Republic of China; 3Department of Bone Injury, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150036, People’s Republic of China
Correspondence: Bo Wang, Department of Bone Injury, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150036, People’s Republic of China, Tel +86-18646246661, Email wb8788000@163.com
Abstract: Osteoarthritis (OA) is a major global contributor to pain, disability, and socioeconomic burden. With the increasing prevalence of obesity and an aging population, the incidence of OA continues to rise. This review explores the bidirectional relationship between obesity and aging in the pathogenesis of OA, focusing on the underlying molecular mechanisms. Obesity contributes to aging by inducing oxidative stress, chronic inflammation, and metabolic dysregulation, thereby promoting OA development and progression. Conversely, the accumulation of senescent cells with age exacerbates obesity-induced inflammation and metabolic dysfunction by secreting pro-inflammatory cytokines and bioactive molecules. Epigenetic changes, including DNA methylation, histone modifications, and the regulation of non-coding RNAs, play pivotal roles in modulating these interactions, further influencing OA progression. The review also discusses current and emerging therapeutic strategies targeting the obesity-aging-OA axis, highlighting the potential of epigenetic interventions and novel anti-inflammatory treatments. A comprehensive understanding of the molecular interplay between obesity and aging in OA is essential for developing more effective prevention and treatment strategies. Future research should prioritize the in-depth exploration of epigenetic mechanisms, coupled with technological innovation, standardized education and training, quality control, and multidisciplinary collaboration. Targeted strategies and interventions are essential to effectively prevent and manage obesity- and OA-related diseases.
Keywords: obesity, aging, osteoarthritis, epigenetics, inflammation