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已发表论文
膝骨关节炎的针灸治疗：临床疗效及神经免疫内分泌机制的叙述性综述
Authors Jiao J , Dong B, Han Y, Zheng Q, Lin X
Received 12 June 2025
Accepted for publication 18 September 2025
Published 25 September 2025 Volume 2025:18 Pages 4989—4998
DOI https://doi.org/10.2147/JPR.S546687
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Houman Danesh
Junru Jiao, Baoqiang Dong, Yiyan Han, Qu Zheng, Xingxing Lin
College of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, People’s Republic of China
Correspondence: Qu Zheng, College of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine, 79 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People’s Republic of China, Email 18540117850@163.com Xingxing Lin, College of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine, 79 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People’s Republic of China, Email 18004012223@163.com
Purpose: Knee osteoarthritis (KOA) is a leading cause of global pain and disability and warrants complementary therapy. This review provides evidence of the clinical efficacy of acupuncture and the multisystem regulatory mechanisms of KOA.
Methods: We analyzed clinical trials and mechanistic studies of acupuncture in the treatment of KOA.
Results: Acupuncture-particularly electroacupuncture (EA) significantly reduced pain (VAS/WOMAC) compared with sham acupuncture and conventional care (P < 0.05). Clinical trials demonstrate that combining acupuncture with exercise significantly enhances functional outcomes. Mechanistically, acupuncture modulates neuroendocrine pathways through three key actions: (1) suppressing pro-inflammatory cytokines (eg, TNF-α, IL-1β); (2) activating the Melatonin/cAMP/PKA/CREB signaling cascade; (3) altering functional connectivity in central pain-processing regions. Controversies persist regarding the mechanisms, optimal techniques, and outcome standardization.
Conclusion: Acupuncture is an effective complementary therapy for KOA. Future research should prioritize long-term efficacy, personalized protocols, technology integration, and multidisciplinary strategies.
Keywords: acupuncture, knee osteoarthritis, pain management, neuroimmune modulation, electroacupuncture, mechanisms
College of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, People’s Republic of China
Correspondence: Qu Zheng, College of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine, 79 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People’s Republic of China, Email 18540117850@163.com Xingxing Lin, College of Acupuncture and Massage, Liaoning University of Traditional Chinese Medicine, 79 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People’s Republic of China, Email 18004012223@163.com
Purpose: Knee osteoarthritis (KOA) is a leading cause of global pain and disability and warrants complementary therapy. This review provides evidence of the clinical efficacy of acupuncture and the multisystem regulatory mechanisms of KOA.
Methods: We analyzed clinical trials and mechanistic studies of acupuncture in the treatment of KOA.
Results: Acupuncture-particularly electroacupuncture (EA) significantly reduced pain (VAS/WOMAC) compared with sham acupuncture and conventional care (P < 0.05). Clinical trials demonstrate that combining acupuncture with exercise significantly enhances functional outcomes. Mechanistically, acupuncture modulates neuroendocrine pathways through three key actions: (1) suppressing pro-inflammatory cytokines (eg, TNF-α, IL-1β); (2) activating the Melatonin/cAMP/PKA/CREB signaling cascade; (3) altering functional connectivity in central pain-processing regions. Controversies persist regarding the mechanisms, optimal techniques, and outcome standardization.
Conclusion: Acupuncture is an effective complementary therapy for KOA. Future research should prioritize long-term efficacy, personalized protocols, technology integration, and multidisciplinary strategies.
Keywords: acupuncture, knee osteoarthritis, pain management, neuroimmune modulation, electroacupuncture, mechanisms