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已发表论文
改良化珀散对寒凝血瘀型月经病患者生殖激素水平及微循环影响的临床研究
Authors Ma R, Zhang N, Xing J, Wang Y, Zhen X
Received 27 May 2025
Accepted for publication 15 September 2025
Published 25 September 2025 Volume 2025:17 Pages 3271—3278
DOI https://doi.org/10.2147/IJWH.S539135
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Vinay Kumar
Ran Ma,1,* Na Zhang,1,* Juan Xing,2 Yan Wang,3 Xi Zhen1
1Department of Infectious Diseases, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of China; 2Department of Obstetrics and Gynecology, Dacheng County Hospital of Traditional Chinese Medicine, Dacheng, Hebei, People’s Republic of China; 3Department of Obstetrics I, Shijiazhuang People’s Hospital, Shijiazhuang, Hebei, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xi Zhen, Department of Infectious Diseases, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of China, Email xqh3533@163.com
Objective: To investigate the effects of Modified Hupo San on reproductive hormone levels and microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern.
Methods: A total of 102 patients from the gynecological outpatient department of our hospital were randomly assigned into a control group (n=51) and a study group (n=51). Randomization was performed using a computer-generated random number table The study group was treated with Modified Hupo San for 3 cycles, while the control group received routine therapy. Blood samples were collected on the 2nd day of menstruation before treatment and again on the 2nd day of the 4th cycle. Serum levels of TXB2, 6-keto-PGF1α, t-PA, PAI-1, estradiol (E2), and progesterone (P) were measured. Safety monitoring was performed throughout the study. Statistical analysis was conducted using SPSS 22.0, with t-tests and chi-square tests applied, and P< 0.05 considered statistically significant.
Results: The total effective rate of Modified Hupo San in treating menstrual disorders of cold congelation and blood stasis pattern was 96.30%. Compared with baseline, serum TXB2 and PAI-1 levels significantly decreased, while 6-keto-PGF1α, t-PA, and t-PA/PAI-1 ratio significantly increased after treatment in the study group. E2 levels significantly increased after treatment, and were higher than those in the control group (P< 0.05). Progesterone showed no significant difference.
Conclusion: Modified Hupo San demonstrated significant therapeutic effects in improving reproductive hormones and regulating microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern, with good safety.
Keywords: cold congelation and blood stasis, menstrual disorder, modified hupo san, reproductive hormones, microcirculation, clinical study
1Department of Infectious Diseases, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of China; 2Department of Obstetrics and Gynecology, Dacheng County Hospital of Traditional Chinese Medicine, Dacheng, Hebei, People’s Republic of China; 3Department of Obstetrics I, Shijiazhuang People’s Hospital, Shijiazhuang, Hebei, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xi Zhen, Department of Infectious Diseases, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, Hebei, People’s Republic of China, Email xqh3533@163.com
Objective: To investigate the effects of Modified Hupo San on reproductive hormone levels and microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern.
Methods: A total of 102 patients from the gynecological outpatient department of our hospital were randomly assigned into a control group (n=51) and a study group (n=51). Randomization was performed using a computer-generated random number table The study group was treated with Modified Hupo San for 3 cycles, while the control group received routine therapy. Blood samples were collected on the 2nd day of menstruation before treatment and again on the 2nd day of the 4th cycle. Serum levels of TXB2, 6-keto-PGF1α, t-PA, PAI-1, estradiol (E2), and progesterone (P) were measured. Safety monitoring was performed throughout the study. Statistical analysis was conducted using SPSS 22.0, with t-tests and chi-square tests applied, and P< 0.05 considered statistically significant.
Results: The total effective rate of Modified Hupo San in treating menstrual disorders of cold congelation and blood stasis pattern was 96.30%. Compared with baseline, serum TXB2 and PAI-1 levels significantly decreased, while 6-keto-PGF1α, t-PA, and t-PA/PAI-1 ratio significantly increased after treatment in the study group. E2 levels significantly increased after treatment, and were higher than those in the control group (P< 0.05). Progesterone showed no significant difference.
Conclusion: Modified Hupo San demonstrated significant therapeutic effects in improving reproductive hormones and regulating microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern, with good safety.
Keywords: cold congelation and blood stasis, menstrual disorder, modified hupo san, reproductive hormones, microcirculation, clinical study