108605
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
免疫细胞介导多部位慢性疼痛与哮喘之间的因果关联：一项中介孟德尔随机化研究
Authors Chen JH , Deng NH, Li YC, Zhu XC, Ge P, Wang XD, Jiang P, Wen ZW, Huang GT, Luo QM, Tu YY
Received 25 April 2025
Accepted for publication 20 September 2025
Published 25 September 2025 Volume 2025:18 Pages 5023—5035
DOI https://doi.org/10.2147/JPR.S536665
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Wendy Imlach
Jie-Hai Chen,1,* Nian-Hua Deng,2,* Yong-Cheng Li,1,* Xiao-Chun Zhu,3 Ping Ge,1 Xiang-Dong Wang,1 Peng Jiang,1 Zhi-Wei Wen,1 Gui-Ting Huang,1 Qing-Ming Luo,4 Yuan-Yan Tu1
1Department of Anesthesiology, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China; 2Department of Anesthesiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, Guangdong Province, 523326, People’s Republic of China; 3Division of Cardiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, Guangdong Province, 523326, People’s Republic of China; 4Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuan-Yan Tu, Department of Anesthesiology, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China, Email jxtuyuan@sina.com Qing-Ming Luo, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China, Email 180115636@qq.com
Background: Cumulative evidence from observational studies has revealed associations between chronic pain (CP) and asthma. However, it remains unclear whether these associations indicate a causal relationship. In this study, we aimed to assess the causal relationships between CP and asthma.
Methods: First, linkage disequilibrium score regression (LDSC) analysis was used to estimate the genetic correlations between 9 types of CP (including multisite chronic pain, knee, back, neck/shoulder, headaches, hip, stomach/abdominal, facial, and general CP) and asthma. Conventional Mendelian randomization (MR) approaches and a new MR method, Causal Analysis Using Summary Effect estimates (CAUSE), were performed to test bidirectional causal relationships between genetically predicted CP and asthma. Finally, mediation analysis was conducted to establish whether immune cells and inflammatory cytokines causally mediate any associations.
Results: For the LDSC analysis, several significant genetic correlations (rg) were observed, such as multisite chronic pain (MCP) and asthma (rg = 0.442, P = 7.23× 10− 52). For the MR analysis, we identified that genetically determined MCP (odds ratio [OR] 2.34, 95% confidence interval [CI] 1.84– 2.97, P = 3.51× 10− 12) was significantly associated with a higher risk of asthma. For the mediation analysis, the three immune-cell phenotypes (including CD3 on activated CD4 regulatory T cells, CD3 on activated and secreting CD4 regulatory T cells, and CD3 on CD39+ CD4+ T cells) were each found to mediate 4.6– 5.0% of the total effect linking MCP to asthma, underscoring their partial mediating role in this causal pathway. Unexpectedly, other types of pain showed no correlation with asthma risk.
Conclusion: Our findings revealed that MCP is significantly associated with a higher risk of asthma, which is partially mediated by immune cells.
Keywords: asthma, chronic pain, causal relationship, Mendelian randomization, mediation analysis
1Department of Anesthesiology, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China; 2Department of Anesthesiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, Guangdong Province, 523326, People’s Republic of China; 3Division of Cardiology, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, Guangdong Province, 523326, People’s Republic of China; 4Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yuan-Yan Tu, Department of Anesthesiology, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China, Email jxtuyuan@sina.com Qing-Ming Luo, Dongguan Maternal and Child Health Care Hospital, Dongguan, Guangdong Province, 523125, People’s Republic of China, Email 180115636@qq.com
Background: Cumulative evidence from observational studies has revealed associations between chronic pain (CP) and asthma. However, it remains unclear whether these associations indicate a causal relationship. In this study, we aimed to assess the causal relationships between CP and asthma.
Methods: First, linkage disequilibrium score regression (LDSC) analysis was used to estimate the genetic correlations between 9 types of CP (including multisite chronic pain, knee, back, neck/shoulder, headaches, hip, stomach/abdominal, facial, and general CP) and asthma. Conventional Mendelian randomization (MR) approaches and a new MR method, Causal Analysis Using Summary Effect estimates (CAUSE), were performed to test bidirectional causal relationships between genetically predicted CP and asthma. Finally, mediation analysis was conducted to establish whether immune cells and inflammatory cytokines causally mediate any associations.
Results: For the LDSC analysis, several significant genetic correlations (rg) were observed, such as multisite chronic pain (MCP) and asthma (rg = 0.442, P = 7.23× 10− 52). For the MR analysis, we identified that genetically determined MCP (odds ratio [OR] 2.34, 95% confidence interval [CI] 1.84– 2.97, P = 3.51× 10− 12) was significantly associated with a higher risk of asthma. For the mediation analysis, the three immune-cell phenotypes (including CD3 on activated CD4 regulatory T cells, CD3 on activated and secreting CD4 regulatory T cells, and CD3 on CD39+ CD4+ T cells) were each found to mediate 4.6– 5.0% of the total effect linking MCP to asthma, underscoring their partial mediating role in this causal pathway. Unexpectedly, other types of pain showed no correlation with asthma risk.
Conclusion: Our findings revealed that MCP is significantly associated with a higher risk of asthma, which is partially mediated by immune cells.
Keywords: asthma, chronic pain, causal relationship, Mendelian randomization, mediation analysis