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已发表论文
眼科中基于智能聚合物的治疗药物的最新进展
Received 24 March 2025
Accepted for publication 28 July 2025
Published 25 September 2025 Volume 2025:20 Pages 11823—11841
DOI https://doi.org/10.2147/IJN.S530124
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Xing Zhang
Jia‘nan Xie, Lili Nie, Ying Pei
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130000, People’s Republic of China
Correspondence: Lili Nie, Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130000, People’s Republic of China, Email niell@jlu.edu.cn
Abstract: Ophthalmic diseases represent a significant burden on global health, contributing to widespread visual impairment and blindness. The distinct anatomical and physiological barriers of the eye significantly restrict the use of conventional ocular delivery techniques. This has prompted research into cutting-edge drug delivery methods that optimize therapeutic benefits and reduce adverse effects. The use of polymer-based drug delivery systems is a promising technique that provides regulated drug release over long periods of time, enhances drug stability, and guarantees localized distribution to specific ocular tissues. This field has been revolutionized by recent advancements in smart polymer-based systems, which enable the development of drug delivery platforms that react dynamically to certain stimuli like pH, temperature, light, and enzymes. By releasing the active pharmaceutical ingredients only when specific conditions are met, these stimuli-responsive devices are intended for delivering medications in a controlled manner, improving treatment precision and minimizing undesirable systemic effects. This review summarizes recent developments in smart polymer-based therapies for ophthalmology, highlighting advances in stimuli-responsive, biodegradable, and multifunctional polymers that have the potential to transform ocular drug delivery, enhance therapeutic efficacy, and improve patient adherence in managing various eye conditions.
Keywords: ocular diseases, nanotechnology, drug delivery, synthetic polymers, biocompatibility
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130000, People’s Republic of China
Correspondence: Lili Nie, Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, 130000, People’s Republic of China, Email niell@jlu.edu.cn
Abstract: Ophthalmic diseases represent a significant burden on global health, contributing to widespread visual impairment and blindness. The distinct anatomical and physiological barriers of the eye significantly restrict the use of conventional ocular delivery techniques. This has prompted research into cutting-edge drug delivery methods that optimize therapeutic benefits and reduce adverse effects. The use of polymer-based drug delivery systems is a promising technique that provides regulated drug release over long periods of time, enhances drug stability, and guarantees localized distribution to specific ocular tissues. This field has been revolutionized by recent advancements in smart polymer-based systems, which enable the development of drug delivery platforms that react dynamically to certain stimuli like pH, temperature, light, and enzymes. By releasing the active pharmaceutical ingredients only when specific conditions are met, these stimuli-responsive devices are intended for delivering medications in a controlled manner, improving treatment precision and minimizing undesirable systemic effects. This review summarizes recent developments in smart polymer-based therapies for ophthalmology, highlighting advances in stimuli-responsive, biodegradable, and multifunctional polymers that have the potential to transform ocular drug delivery, enhance therapeutic efficacy, and improve patient adherence in managing various eye conditions.
Keywords: ocular diseases, nanotechnology, drug delivery, synthetic polymers, biocompatibility