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已发表论文
超声在新疆地区胎儿圆锥间隔偏斜角度及偏移距离检测中的价值在早期诊断胎儿圆锥动脉干畸形中的应用
Authors Zhang F , Wei W, Chen Y, Hu B, Zhang L, Lin Z, Niu M , Ding S, Jiang F, Yang H, Mao L, Pan J
Received 3 April 2025
Accepted for publication 3 September 2025
Published 25 September 2025 Volume 2025:16 Pages 31—40
DOI https://doi.org/10.2147/RRCC.S527288
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Yuriy Sirenko
Fengling Zhang,1 Wei Wei,2 Yonglin Chen,3 Bo Hu,4 Li Zhang,3 Zhaotang Lin,1 Muqing Niu,1 Shupei Ding,1 Fang Jiang,1 Hongbin Yang,5 Lian Mao,6 Jinyong Pan3
1Department of Pediatrics, School of Clinical Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 3Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 4Department of Interventional Radiology, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 5Department of Pediatrics, Korla Hospital of The Second Division of Xinjiang Production and Construction Corps, Korla, Xinjiang Uygur Autonomous Region, People’s Republic of China; 6Department of Pediatrics, Hospital of the Third Division, Xinjiang Production and Construction Corps, Kashgar, Xinjiang Uygur Autonomous Region, People’s Republic of China
Correspondence: Jinyong Pan, Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China, Email 63620441@qq.com
Objective: To evaluate the diagnostic value of conal septum deflection angle and deviation distance in the early ultrasonographic detection of fetal conotruncal heart defects (CTDs) in Xinjiang, China.
Methods: Between January 2021 and December 2024, a total of 80 fetuses with CTDs and 80 gestational age–matched healthy controls were enrolled from three tertiary centers. Three-dimensional fetal echocardiography was performed to measure the conal septum deflection angle and maximum deviation distance in the anterior–posterior (AP), left–right (LR), and up–down (UD) orientations. Group comparisons were conducted among tetralogy of Fallot (TOF), double outlet right ventricle (DORV), transposition of the great arteries (D-TGA), and controls using Welch’s ANOVA, Kruskal–Wallis tests, and post hoc pairwise analyses.
Results: Both TOF and DORV groups exhibited significantly larger AP and LR deflection angles than controls (P< 0.001), whereas D-TGA showed increased AP angle but no significant LR difference (P≈0.30). UD angles were significantly smaller in all CTD subtypes compared with controls (all P< 0.001). Deviation distances followed similar trends, with DORV presenting the largest AP and LR displacement (32.50 ± 3.07 mm and 31.73 ± 3.83 mm, respectively), significantly greater than TOF and D-TGA (all P< 0.001). Hedges’ g indicated very large effect sizes for AP displacement in DORV (g = 15.29) and TOF (g = 7.90).
Conclusion: Quantitative assessment of conal septum deflection angle and deviation distance reveals distinct geometric signatures among CTD subtypes, with DORV showing the most pronounced abnormalities. Three-dimensional echocardiographic measurement of these parameters provides a reproducible and sensitive approach for early CTD detection, facilitating accurate prenatal diagnosis and perinatal management planning.
Keywords: fetal echocardiography, conotruncal heart defects, conal septum deflection, prenatal diagnosis, three-dimensional ultrasound
1Department of Pediatrics, School of Clinical Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2Department of Ultrasound, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 3Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 4Department of Interventional Radiology, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China; 5Department of Pediatrics, Korla Hospital of The Second Division of Xinjiang Production and Construction Corps, Korla, Xinjiang Uygur Autonomous Region, People’s Republic of China; 6Department of Pediatrics, Hospital of the Third Division, Xinjiang Production and Construction Corps, Kashgar, Xinjiang Uygur Autonomous Region, People’s Republic of China
Correspondence: Jinyong Pan, Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China, Email 63620441@qq.com
Objective: To evaluate the diagnostic value of conal septum deflection angle and deviation distance in the early ultrasonographic detection of fetal conotruncal heart defects (CTDs) in Xinjiang, China.
Methods: Between January 2021 and December 2024, a total of 80 fetuses with CTDs and 80 gestational age–matched healthy controls were enrolled from three tertiary centers. Three-dimensional fetal echocardiography was performed to measure the conal septum deflection angle and maximum deviation distance in the anterior–posterior (AP), left–right (LR), and up–down (UD) orientations. Group comparisons were conducted among tetralogy of Fallot (TOF), double outlet right ventricle (DORV), transposition of the great arteries (D-TGA), and controls using Welch’s ANOVA, Kruskal–Wallis tests, and post hoc pairwise analyses.
Results: Both TOF and DORV groups exhibited significantly larger AP and LR deflection angles than controls (P< 0.001), whereas D-TGA showed increased AP angle but no significant LR difference (P≈0.30). UD angles were significantly smaller in all CTD subtypes compared with controls (all P< 0.001). Deviation distances followed similar trends, with DORV presenting the largest AP and LR displacement (32.50 ± 3.07 mm and 31.73 ± 3.83 mm, respectively), significantly greater than TOF and D-TGA (all P< 0.001). Hedges’ g indicated very large effect sizes for AP displacement in DORV (g = 15.29) and TOF (g = 7.90).
Conclusion: Quantitative assessment of conal septum deflection angle and deviation distance reveals distinct geometric signatures among CTD subtypes, with DORV showing the most pronounced abnormalities. Three-dimensional echocardiographic measurement of these parameters provides a reproducible and sensitive approach for early CTD detection, facilitating accurate prenatal diagnosis and perinatal management planning.
Keywords: fetal echocardiography, conotruncal heart defects, conal septum deflection, prenatal diagnosis, three-dimensional ultrasound