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已发表论文
质子泵抑制剂治疗可缩短喉癌术后肉芽组织持续时间：一项回顾性队列研究
Authors Wang J, Zhang C, Liu Y
Received 3 June 2025
Accepted for publication 16 September 2025
Published 25 September 2025 Volume 2025:17 Pages 2169—2181
DOI https://doi.org/10.2147/CMAR.S544365
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Yong Teng
Jingjing Wang,1 Chunhe Zhang,2 Yanan Liu3
1Department of Pharmacy, Cangzhou People’s Hospital, Cangzhou, Hebei, People’s Republic of China; 2Department of Laboratory Medicine, Cangzhou People’s Hospital, Cangzhou, Hebei, People’s Republic of China; 3Department of Otorhinolaryngology, Cangzhou People’s Hospital, Cangzhou, Hebei, People’s Republic of China
Correspondence: Yanan Liu, Department of Otorhinolaryngology, Cangzhou People’s Hospital, No. 7 Qingchi North Avenue, Xinhua District, Cangzhou, Hebei, 061000, People’s Republic of China, Email liuyanan99500@163.com
Background: Granulation tissue formation complicates laryngeal cancer surgery recovery and may be exacerbated by laryngopharyngeal reflux. We investigated whether postoperative proton pump inhibitor (PPI) therapy reduces granulation tissue duration through reflux-mediated mechanisms.
Methods: This retrospective cohort study included 89 laryngeal cancer patients undergoing function-preserving surgery (May 2020-December 2024). Patients received either postoperative PPI therapy (n=32) or standard care (n=57). Primary endpoint was granulation tissue duration. Secondary endpoints included Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) changes. Mediation analysis explored whether PPI effects operated through reflux improvement.
Results: Granulation formation rates were comparable between groups (65.6% vs 57.9%, P=0.188). Among patients developing granulation tissue (n=54), the PPI group demonstrated significantly shorter duration (4.0 [4.0, 5.0] vs 8.0 [6.0, 9.0] weeks, P< 0.001). PPI therapy produced superior improvements in RSI (14.0 [13.0, 16.0] vs 4.0 [3.0, 4.0], P< 0.001) and RFS scores (8.0 [6.8, 9.0] vs 2.0 [1.0, 3.0], P< 0.001). Strong negative correlations existed between reflux improvement and granulation duration (RSI: r=− 0.76; RFS: r=− 0.74, both P< 0.001). Mediation analysis revealed RSI improvement accounted for 16.18% of PPI’s therapeutic effect. Benefits were most pronounced in females, early-stage tumors, and patients with lower baseline RSI scores.
Conclusion: Postoperative PPI therapy significantly reduces granulation tissue duration following laryngeal cancer surgery through both reflux-dependent and independent mechanisms, supporting routine perioperative acid suppression in this population.
Keywords: laryngeal cancer, granulation tissue, proton pump inhibitors, laryngopharyngeal reflux
1Department of Pharmacy, Cangzhou People’s Hospital, Cangzhou, Hebei, People’s Republic of China; 2Department of Laboratory Medicine, Cangzhou People’s Hospital, Cangzhou, Hebei, People’s Republic of China; 3Department of Otorhinolaryngology, Cangzhou People’s Hospital, Cangzhou, Hebei, People’s Republic of China
Correspondence: Yanan Liu, Department of Otorhinolaryngology, Cangzhou People’s Hospital, No. 7 Qingchi North Avenue, Xinhua District, Cangzhou, Hebei, 061000, People’s Republic of China, Email liuyanan99500@163.com
Background: Granulation tissue formation complicates laryngeal cancer surgery recovery and may be exacerbated by laryngopharyngeal reflux. We investigated whether postoperative proton pump inhibitor (PPI) therapy reduces granulation tissue duration through reflux-mediated mechanisms.
Methods: This retrospective cohort study included 89 laryngeal cancer patients undergoing function-preserving surgery (May 2020-December 2024). Patients received either postoperative PPI therapy (n=32) or standard care (n=57). Primary endpoint was granulation tissue duration. Secondary endpoints included Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) changes. Mediation analysis explored whether PPI effects operated through reflux improvement.
Results: Granulation formation rates were comparable between groups (65.6% vs 57.9%, P=0.188). Among patients developing granulation tissue (n=54), the PPI group demonstrated significantly shorter duration (4.0 [4.0, 5.0] vs 8.0 [6.0, 9.0] weeks, P< 0.001). PPI therapy produced superior improvements in RSI (14.0 [13.0, 16.0] vs 4.0 [3.0, 4.0], P< 0.001) and RFS scores (8.0 [6.8, 9.0] vs 2.0 [1.0, 3.0], P< 0.001). Strong negative correlations existed between reflux improvement and granulation duration (RSI: r=− 0.76; RFS: r=− 0.74, both P< 0.001). Mediation analysis revealed RSI improvement accounted for 16.18% of PPI’s therapeutic effect. Benefits were most pronounced in females, early-stage tumors, and patients with lower baseline RSI scores.
Conclusion: Postoperative PPI therapy significantly reduces granulation tissue duration following laryngeal cancer surgery through both reflux-dependent and independent mechanisms, supporting routine perioperative acid suppression in this population.
Keywords: laryngeal cancer, granulation tissue, proton pump inhibitors, laryngopharyngeal reflux