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已发表论文
中国结肠息肉病诊断与治疗现状：基于中国研究的见解及与日本病例的比较分析
Authors Liu X, Xu W, Gao Z, Gao B, Zhang L, Zheng Y, Zhang D, Gao Y, Jin S
Received 8 June 2025
Accepted for publication 13 September 2025
Published 25 September 2025 Volume 2025:18 Pages 5777—5801
DOI https://doi.org/10.2147/IJGM.S545573
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Gopal Krishna Dhali
Xiaobo Liu,1,2 Wen Xu,1 Ziye Gao,3 Bo Gao,4 Lu Zhang,1 Yanyan Zheng,1 Danqin Zhang,1 Yuanjun Gao,1 Shu Jin1
1Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 2Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 3Department of Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 4Department of Assessment Office, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China
Correspondence: Shu Jin, Email jinshu76@sohu.com Yuanjun Gao, Email 345684956@qq.com
Background: Cap polyposis (CP) is a rare, non-neoplastic colorectal disorder characterized by inflammatory polyps with distinctive endoscopic and histopathological features. Although increasingly reported, particularly in East Asian populations, its etiology remains unclear, and diagnostic and treatment strategies are not well standardized. Previous studies have been limited by small sample sizes and regional focus. This review aims to systematically analyze the clinical characteristics, management, and outcomes of CP in Chinese patients, with comparative insights from Japanese cases, to improve understanding and guide clinical practice.
Methods: A systematic literature search was conducted in PubMed, EMBASE, Cochrane Library, CNKI, and Wanfang databases for studies published before October 2023. Keywords included “cap polyposis” and “cap-shaped polyp”. Articles were screened against predefined inclusion criteria: studies from Mainland China, pathologically confirmed CP cases, and availability of clinical and therapeutic data. Data extraction and quality assessment were performed independently by two reviewers using the Newcastle–Ottawa Scale.
Results: Fourteen studies involving 57 patients were included. The most common symptoms were hematochezia (59.6%) and diarrhea (28.1%). Polyps were predominantly located in the rectum (68.4%), and 66.7% of patients had three or more polyps. Helicobacter pylori testing was positive in 57.1% of tested patients (12/21). Comparative analysis with Japanese cases revealed similar rectal predominance but suggested potential variations in gender distribution and treatment preferences. Treatments included endoscopic mucosal resection, endoscopic submucosal dissection, H. pylori eradication, and surgery. During a median follow-up of 14 months, 10 patients experienced recurrence.
Conclusion: CP is a benign but easily misdiagnosed condition with a high recurrence rate. Diagnosis relies on combined endoscopic and histopathological findings. Treatment remains empirical, with H. pylori eradication beneficial in infected patients, and endoscopic resection effective for localized disease. Further multicenter studies are needed to establish standardized management protocols.
Keywords: cap polyposis, cap-shaped polyp, China, Helicobacter pylori, endoscopic mucosal resection, endoscopic submucosal dissection
1Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 2Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 3Department of Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China; 4Department of Assessment Office, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China
Correspondence: Shu Jin, Email jinshu76@sohu.com Yuanjun Gao, Email 345684956@qq.com
Background: Cap polyposis (CP) is a rare, non-neoplastic colorectal disorder characterized by inflammatory polyps with distinctive endoscopic and histopathological features. Although increasingly reported, particularly in East Asian populations, its etiology remains unclear, and diagnostic and treatment strategies are not well standardized. Previous studies have been limited by small sample sizes and regional focus. This review aims to systematically analyze the clinical characteristics, management, and outcomes of CP in Chinese patients, with comparative insights from Japanese cases, to improve understanding and guide clinical practice.
Methods: A systematic literature search was conducted in PubMed, EMBASE, Cochrane Library, CNKI, and Wanfang databases for studies published before October 2023. Keywords included “cap polyposis” and “cap-shaped polyp”. Articles were screened against predefined inclusion criteria: studies from Mainland China, pathologically confirmed CP cases, and availability of clinical and therapeutic data. Data extraction and quality assessment were performed independently by two reviewers using the Newcastle–Ottawa Scale.
Results: Fourteen studies involving 57 patients were included. The most common symptoms were hematochezia (59.6%) and diarrhea (28.1%). Polyps were predominantly located in the rectum (68.4%), and 66.7% of patients had three or more polyps. Helicobacter pylori testing was positive in 57.1% of tested patients (12/21). Comparative analysis with Japanese cases revealed similar rectal predominance but suggested potential variations in gender distribution and treatment preferences. Treatments included endoscopic mucosal resection, endoscopic submucosal dissection, H. pylori eradication, and surgery. During a median follow-up of 14 months, 10 patients experienced recurrence.
Conclusion: CP is a benign but easily misdiagnosed condition with a high recurrence rate. Diagnosis relies on combined endoscopic and histopathological findings. Treatment remains empirical, with H. pylori eradication beneficial in infected patients, and endoscopic resection effective for localized disease. Further multicenter studies are needed to establish standardized management protocols.
Keywords: cap polyposis, cap-shaped polyp, China, Helicobacter pylori, endoscopic mucosal resection, endoscopic submucosal dissection