108605
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
脊髓损伤修复的进展：导电水凝胶在神经组织工程中的作用
Authors Du H , Zhao J, Wang J , Yang X , Pan S
Received 11 July 2025
Accepted for publication 19 September 2025
Published 24 September 2025 Volume 2025:20 Pages 11781—11802
DOI https://doi.org/10.2147/IJN.S553136
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Kamakhya Misra
Haorui Du,1 Jie Zhao,2 Jintao Wang,1 Xiaoyu Yang,1 Su Pan1
1Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, 130022, People’s Republic of China; 2Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, 130022, People’s Republic of China
Correspondence: Su Pan, Email pansu@jlu.edu.cn Xiaoyu Yang, Email yangxiaoy@jlu.edu.cn
Abstract: Spinal Cord Injury (SCI) is a devastating condition of the central nervous system, affecting a significant number of individuals globally. It leads to irreversible motor, sensory, and autonomic dysfunctions, placing a substantial burden on both patients and society. As a result, there is an urgent need for more effective therapeutic strategies. In recent years, the field of neurotissue engineering has made remarkable progress, offering new avenues for spinal cord injury repair. Among these advancements, conductive hydrogels have gained considerable attention due to their ability to mimic the electrical signaling properties of the spinal cord. These hydrogels not only replicate the complex electrical environment of the spinal cord but also enable non-invasive modulation of electrical signals, which can influence neuronal cell behavior. Additionally, conductive hydrogels provide essential mechanical support and serve as carriers for various drugs, bioactive factors, and cells, which can restore the disrupted microenvironment and promote axonal regeneration, remyelination, and functional recovery after SCI. This paper thoroughly investigates the pathophysiological mechanisms underlying SCI, systematically analyzes the different types of conductive materials used in hydrogels, and evaluates their combinations and functions. Furthermore, it discusses the technical challenges, bottlenecks, and future directions for the development of functional biomaterials aimed at effective SCI repair, offering insights for the creation of innovative therapeutic strategies.
Keywords: conductive hydrogels, neural tissue engineering, electrical stimulation, spinal cord injury
1Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, 130022, People’s Republic of China; 2Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin Province, 130022, People’s Republic of China
Correspondence: Su Pan, Email pansu@jlu.edu.cn Xiaoyu Yang, Email yangxiaoy@jlu.edu.cn
Abstract: Spinal Cord Injury (SCI) is a devastating condition of the central nervous system, affecting a significant number of individuals globally. It leads to irreversible motor, sensory, and autonomic dysfunctions, placing a substantial burden on both patients and society. As a result, there is an urgent need for more effective therapeutic strategies. In recent years, the field of neurotissue engineering has made remarkable progress, offering new avenues for spinal cord injury repair. Among these advancements, conductive hydrogels have gained considerable attention due to their ability to mimic the electrical signaling properties of the spinal cord. These hydrogels not only replicate the complex electrical environment of the spinal cord but also enable non-invasive modulation of electrical signals, which can influence neuronal cell behavior. Additionally, conductive hydrogels provide essential mechanical support and serve as carriers for various drugs, bioactive factors, and cells, which can restore the disrupted microenvironment and promote axonal regeneration, remyelination, and functional recovery after SCI. This paper thoroughly investigates the pathophysiological mechanisms underlying SCI, systematically analyzes the different types of conductive materials used in hydrogels, and evaluates their combinations and functions. Furthermore, it discusses the technical challenges, bottlenecks, and future directions for the development of functional biomaterials aimed at effective SCI repair, offering insights for the creation of innovative therapeutic strategies.
Keywords: conductive hydrogels, neural tissue engineering, electrical stimulation, spinal cord injury