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已发表论文
乳腺癌疼痛的神经影像学进展：综述
Authors Wei P, Liu Y, Tong J, Zhang Q, Qiu Z, Xu X
Received 15 May 2025
Accepted for publication 2 September 2025
Published 24 September 2025 Volume 2025:18 Pages 4975—4988
DOI https://doi.org/10.2147/JPR.S540502
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Amitabh Gulati
Pu Wei, Yuqing Liu, Jinming Tong, Qingwei Zhang, Zhiqiang Qiu, Xiaoxue Xu
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China
Correspondence: Xiaoxue Xu, Email nclittlesnownc@163.com
Abstract: Breast cancer is currently the most common malignant tumor, primarily affecting women, and it frequently leads to chronic pain that significantly impairs physical and mental health. Neuroimaging studies have demonstrated that breast cancer-related pain is associated with specific brain alterations, including changes in activation, connectivity, and structure of pain-processing regions. This review synthesizes findings on functional and structural brain changes related to chronic pain in breast cancer and compares them with non-cancer chronic pain patterns. By integrating recent evidence, it proposes a conceptual framework to advance the understanding of pain mechanisms and supports personalized pain management strategies to improve quality of life.
Keywords: breast cancer, chronic pain, brain function, resting-state fMRI, diffusion tensor imaging
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China
Correspondence: Xiaoxue Xu, Email nclittlesnownc@163.com
Abstract: Breast cancer is currently the most common malignant tumor, primarily affecting women, and it frequently leads to chronic pain that significantly impairs physical and mental health. Neuroimaging studies have demonstrated that breast cancer-related pain is associated with specific brain alterations, including changes in activation, connectivity, and structure of pain-processing regions. This review synthesizes findings on functional and structural brain changes related to chronic pain in breast cancer and compares them with non-cancer chronic pain patterns. By integrating recent evidence, it proposes a conceptual framework to advance the understanding of pain mechanisms and supports personalized pain management strategies to improve quality of life.
Keywords: breast cancer, chronic pain, brain function, resting-state fMRI, diffusion tensor imaging