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已发表论文
美国门诊成年患者久坐生活方式、身体活动与皮肤癌之间的关联：来自 NHANES 的证据
Authors Qiu ZQ, Ye SY, Zhang RD, Cao M, Wang Y
Received 8 June 2025
Accepted for publication 17 September 2025
Published 24 September 2025 Volume 2025:18 Pages 2439—2450
DOI https://doi.org/10.2147/CCID.S545546
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Michela Starace
Ze-Qun Qiu, Shan-Yuan Ye, Run-Dong Zhang, Meng Cao, Yan Wang
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, People’s Republic of China
Correspondence: Yan Wang, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 12 Jiangwangmiao Street, Xuanwu District, Nanjing, Jiangsu, People’s Republic of China, Email wangy@pumcderm.cams.cn
Background: Sedentary behavior has been identified as a potential risk factor for various malignancies, whereas physical activity serves as a protective factor for certain cancers. The aim of this study was to explore the associations between these two factors and the prevalence of melanoma and non-melanoma skin cancers (NMSCs).
Methods: We collected cross-sectional data from 26,731 participants in the NHANES from 2007 to 2016. Multivariate logistic regression and subgroup analyses were used to assess the correlations between sedentary behavior, physical activity, and the prevalence of melanoma and NMSCs.
Results: Multivariable logistic regression indicated that sedentary behavior was not significantly associated with melanoma or NMSCs. The type and score of physical activity were not related to melanoma (p > 0.05). However, moderate-intensity physical activity (including both work and recreation activities) and physical activity scores in the 2001– 4000 range were positively correlated with NMSCs. Subgroup analysis and interaction tests showed no significant differences in NMSC prevalence between participants with a physical activity score ranging from 2001– 4000, suggesting that gender, Poverty Income Ratio (PIR), and education level were not significantly related to this positive correlation (p < 0.05). However, after adjusting for UV radiation as a covariate, the logistic regression results of the NMSCs were no longer significant.
Conclusion: Our study results indicate that, for individuals aged 20 and above in the US, SB is not associated with the prevalence of melanoma or NMSCs. There is no significant correlation between physical activity and the prevalence of melanoma, but a positive correlation exists with NMSCs’. However, this association was attenuated and lost statistical significance after adjustment for sunburn history as a proxy for UV exposure. We need more prospective and well-designed studies to validate our findings to promote early prevention and lifestyle interventions for high-risk populations of NMSCs.
Keywords: physical activity, sedentary behavior, melanoma, non-melanoma skin cancer, public health
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, People’s Republic of China
Correspondence: Yan Wang, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 12 Jiangwangmiao Street, Xuanwu District, Nanjing, Jiangsu, People’s Republic of China, Email wangy@pumcderm.cams.cn
Background: Sedentary behavior has been identified as a potential risk factor for various malignancies, whereas physical activity serves as a protective factor for certain cancers. The aim of this study was to explore the associations between these two factors and the prevalence of melanoma and non-melanoma skin cancers (NMSCs).
Methods: We collected cross-sectional data from 26,731 participants in the NHANES from 2007 to 2016. Multivariate logistic regression and subgroup analyses were used to assess the correlations between sedentary behavior, physical activity, and the prevalence of melanoma and NMSCs.
Results: Multivariable logistic regression indicated that sedentary behavior was not significantly associated with melanoma or NMSCs. The type and score of physical activity were not related to melanoma (p > 0.05). However, moderate-intensity physical activity (including both work and recreation activities) and physical activity scores in the 2001– 4000 range were positively correlated with NMSCs. Subgroup analysis and interaction tests showed no significant differences in NMSC prevalence between participants with a physical activity score ranging from 2001– 4000, suggesting that gender, Poverty Income Ratio (PIR), and education level were not significantly related to this positive correlation (p < 0.05). However, after adjusting for UV radiation as a covariate, the logistic regression results of the NMSCs were no longer significant.
Conclusion: Our study results indicate that, for individuals aged 20 and above in the US, SB is not associated with the prevalence of melanoma or NMSCs. There is no significant correlation between physical activity and the prevalence of melanoma, but a positive correlation exists with NMSCs’. However, this association was attenuated and lost statistical significance after adjustment for sunburn history as a proxy for UV exposure. We need more prospective and well-designed studies to validate our findings to promote early prevention and lifestyle interventions for high-risk populations of NMSCs.
Keywords: physical activity, sedentary behavior, melanoma, non-melanoma skin cancer, public health