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已发表论文
聚焦于感染严重发热伴血小板减少综合征病毒（SFTSV）后宿主淋巴细胞水平变化机制的研究
Authors Chen Y, Miller H, Benlagha K , Byazrova MG, Filatov AV, Zhang Z, Liu L, Ding Y, Yang L , Gong Q, Liu C
Received 28 March 2025
Accepted for publication 29 July 2025
Published 24 September 2025 Volume 2025:18 Pages 13265—13277
DOI https://doi.org/10.2147/JIR.S531068
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Tara Strutt
Yundi Chen,1 Heather Miller,2 Kamel Benlagha,3 Maria G Byazrova,4 Alexander V Filatov,4 Ziyin Zhang,1 Lian Liu,5 Yan Ding,6 Lu Yang,1 Quan Gong,5 Chaohong Liu1
1Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, USA; 3Institut de Recherche Saint-Louis, Université de Paris, Paris, France; 4Laboratory of Immunochemistry, National Research Center Institute of Immunology, Federal Medical Biological Agency of Russia, Moscow, Russia; 5Department of Immunology, School of Medicine, Yangtze University, Jingzhou, People’s Republic of China; 6Department of Rheumatology and Immunology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
Correspondence: Quan Gong, Department of Immunology, School of Medicine, Yangtze University, Jingzhou, People’s Republic of China, Email gongquan1998@163.com Chaohong Liu, Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China, Email chaohongliu80@126.com
Abstract: Nowadays, severe fever with thrombocytopenia syndrome (SFTS), featuring clinical manifestation of fever with leukopenia, thrombocytopenia and multiple organ function impairment, has been paid more and more attention. It has become the pandemic for a few years and a quantity of people died of it. Severe fever with thrombocytopenia syndrome virus (SFTSV) infection may lead to the development of SFTS, which is characterized by decreased counts of lymphocyte subsets, especially T cells, B cells and natural killer cells, and disruptive release of cytokines, chemokines and growth factors. However, the deeper mechanism of this disease remains unidentified. To excavate the mechanisms of lymphopenia in SFTSV infection and to introduce the potential therapeutics, this paper focuses on lymphopenia as well as reviews the mechanisms and effects of lymphopenia caused by SFTSV infection, mainly through making analogies with other similar viruses to explain the details of programmed cell death. Other factors such as IL-6,IL-10, TNF-α and some vital immunocytes also play significant roles in eliciting lymphopenia. Eventually, the probable clinical implications have been discussed, mentioning that lymphopenia induced by multiple pathways in SFTSV infection may be associated with the severity of viral disease and opportunistic infection.
Keywords: lymphopenia, SFTSV, cytokines, chemokines, infection, immune response
1Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, USA; 3Institut de Recherche Saint-Louis, Université de Paris, Paris, France; 4Laboratory of Immunochemistry, National Research Center Institute of Immunology, Federal Medical Biological Agency of Russia, Moscow, Russia; 5Department of Immunology, School of Medicine, Yangtze University, Jingzhou, People’s Republic of China; 6Department of Rheumatology and Immunology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China
Correspondence: Quan Gong, Department of Immunology, School of Medicine, Yangtze University, Jingzhou, People’s Republic of China, Email gongquan1998@163.com Chaohong Liu, Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People’s Republic of China, Email chaohongliu80@126.com
Abstract: Nowadays, severe fever with thrombocytopenia syndrome (SFTS), featuring clinical manifestation of fever with leukopenia, thrombocytopenia and multiple organ function impairment, has been paid more and more attention. It has become the pandemic for a few years and a quantity of people died of it. Severe fever with thrombocytopenia syndrome virus (SFTSV) infection may lead to the development of SFTS, which is characterized by decreased counts of lymphocyte subsets, especially T cells, B cells and natural killer cells, and disruptive release of cytokines, chemokines and growth factors. However, the deeper mechanism of this disease remains unidentified. To excavate the mechanisms of lymphopenia in SFTSV infection and to introduce the potential therapeutics, this paper focuses on lymphopenia as well as reviews the mechanisms and effects of lymphopenia caused by SFTSV infection, mainly through making analogies with other similar viruses to explain the details of programmed cell death. Other factors such as IL-6,IL-10, TNF-α and some vital immunocytes also play significant roles in eliciting lymphopenia. Eventually, the probable clinical implications have been discussed, mentioning that lymphopenia induced by multiple pathways in SFTSV infection may be associated with the severity of viral disease and opportunistic infection.
Keywords: lymphopenia, SFTSV, cytokines, chemokines, infection, immune response