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已发表论文
高敏 C 反应蛋白与动脉硬化纵向变化随时间推移的关联：开滦前瞻性队列研究
Authors Li W , Liang P, Han Z, Liu X, An S, Wang X, Gao Y , Chen S, Wu S
Received 14 June 2025
Accepted for publication 13 September 2025
Published 24 September 2025 Volume 2025:18 Pages 13255—13264
DOI https://doi.org/10.2147/JIR.S541222
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Qing Lin
Weizhe Li,1,* Pei Liang,2,* Zhao Han,3 Xiaohui Liu,4 Shasha An,5 Xin Wang,1 Yanling Gao,1 Shuohua Chen,6 Shouling Wu6
1Department of Emergency Internal Medicine No. I, Handan Central Hospital, Handan, Hebei, 056001, People’s Republic of China; 2Rehabilitation Department Three, Handan Mingren Hospital, Handan, Hebei, 056001, People’s Republic of China; 3Department of Dermatology, The Affiliated Hospital of Hebei Engineering University, Handan, Hebei, 056002, People’s Republic of China; 4Department of General Surgery II, Handan Central Hospital, Handan, Hebei, 056001, People’s Republic of China; 5Department of General Medicine, Handan Central Hospital, Handan, Hebei, 056001, People’s Republic of China; 6Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei, 063001, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaohui Liu, Department of General Surgery II, Handan Central Hospital, NO. 15, Zhonghuanan Street, Hanshan District, Handan, Hebei, 056001, People’s Republic of China, Tel: +86 18630004402, Email liuhui-10@163.com
Objective: To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) and the longitudinal changes in arterial Arteriosclerosis over time.
Methods: Using a prospective cohort study design, 25,336 participants from the Kailuan study cohort, who had completed at least two baPWV measurements and met the inclusion criteria, included in the analysis. Participants were divided into three groups based on baseline hs-CRP levels: hs-CRP< 1 mg/L, 1 mg/L≤hs-CRP≤ 3 mg/L, and hs-CRP > 3 mg/L. The relationship between hs-CRP and the longitudinal changes in baPWV was analyzed using a linear mixed-effects model.
Results: (1) The average follow-up duration was 4.62 ± 2.86 years. At the end of the follow-up, the baPWV of the three groups:hs-CRP < 1 mg/L (n=11,651), 1 mg/L ≤ hs-CRP ≤ 3 mg/L (n=9,369), and hs-CRP > 3 mg/L (n=4,316) increased over time. The average rate of increase in baPWV was 84.26 cm/s, 88.06 cm/s, and 73.92 cm/s, respectively. (2) The linear mixed-effects model analysis of factors affecting the progression of Arteriosclerosis, after adjusting for confounding factors, showed that compared to the hsCRP_1 group, the baPWV increase rate in the hsCRP_2 and hsCRP_3 groups was progressively higher. The effect Estimate were 14.4 cm/s (95% CI 6.54 to 22.34, P< 0.001) and 40.67 cm/s (95% CI 5.28 to 51.02, P< 0.001), respectively. Stratifying by gender showed that the impact was more pronounced in males, with effect Estimate of 20.56 cm/s (95% CI 6.18 to 8.45, P< 0.001) and 43.06 cm/s (95% CI 27.82 to 58.31, P< 0.001), respectively. Sensitivity analysis confirmed that this longitudinal association was more pronounced.
Conclusion: There is a significant “dose-response” relationship between hs-CRP and the longitudinal progression of Arteriosclerosis, with a more pronounced effect observed in the male population.
Keywords: high-sensitivity C-reactive protein, ankle-brachial pulse wave velocity, arteriosclerosis, linear mixed-effects model
1Department of Emergency Internal Medicine No. I, Handan Central Hospital, Handan, Hebei, 056001, People’s Republic of China; 2Rehabilitation Department Three, Handan Mingren Hospital, Handan, Hebei, 056001, People’s Republic of China; 3Department of Dermatology, The Affiliated Hospital of Hebei Engineering University, Handan, Hebei, 056002, People’s Republic of China; 4Department of General Surgery II, Handan Central Hospital, Handan, Hebei, 056001, People’s Republic of China; 5Department of General Medicine, Handan Central Hospital, Handan, Hebei, 056001, People’s Republic of China; 6Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei, 063001, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaohui Liu, Department of General Surgery II, Handan Central Hospital, NO. 15, Zhonghuanan Street, Hanshan District, Handan, Hebei, 056001, People’s Republic of China, Tel: +86 18630004402, Email liuhui-10@163.com
Objective: To investigate the relationship between high-sensitivity C-reactive protein (hs-CRP) and the longitudinal changes in arterial Arteriosclerosis over time.
Methods: Using a prospective cohort study design, 25,336 participants from the Kailuan study cohort, who had completed at least two baPWV measurements and met the inclusion criteria, included in the analysis. Participants were divided into three groups based on baseline hs-CRP levels: hs-CRP< 1 mg/L, 1 mg/L≤hs-CRP≤ 3 mg/L, and hs-CRP > 3 mg/L. The relationship between hs-CRP and the longitudinal changes in baPWV was analyzed using a linear mixed-effects model.
Results: (1) The average follow-up duration was 4.62 ± 2.86 years. At the end of the follow-up, the baPWV of the three groups:hs-CRP < 1 mg/L (n=11,651), 1 mg/L ≤ hs-CRP ≤ 3 mg/L (n=9,369), and hs-CRP > 3 mg/L (n=4,316) increased over time. The average rate of increase in baPWV was 84.26 cm/s, 88.06 cm/s, and 73.92 cm/s, respectively. (2) The linear mixed-effects model analysis of factors affecting the progression of Arteriosclerosis, after adjusting for confounding factors, showed that compared to the hsCRP_1 group, the baPWV increase rate in the hsCRP_2 and hsCRP_3 groups was progressively higher. The effect Estimate were 14.4 cm/s (95% CI 6.54 to 22.34, P< 0.001) and 40.67 cm/s (95% CI 5.28 to 51.02, P< 0.001), respectively. Stratifying by gender showed that the impact was more pronounced in males, with effect Estimate of 20.56 cm/s (95% CI 6.18 to 8.45, P< 0.001) and 43.06 cm/s (95% CI 27.82 to 58.31, P< 0.001), respectively. Sensitivity analysis confirmed that this longitudinal association was more pronounced.
Conclusion: There is a significant “dose-response” relationship between hs-CRP and the longitudinal progression of Arteriosclerosis, with a more pronounced effect observed in the male population.
Keywords: high-sensitivity C-reactive protein, ankle-brachial pulse wave velocity, arteriosclerosis, linear mixed-effects model