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已发表论文
针刀术对膝骨关节炎软骨细胞焦亡中 NLRP3/Caspase-1/GSDMD 通路的调节作用
Authors Wang Y, Chen Y, Yang Y, Zhou Y, Yang Y, Zhu J
Received 7 May 2025
Accepted for publication 16 September 2025
Published 23 September 2025 Volume 2025:18 Pages 4935—4945
DOI https://doi.org/10.2147/JPR.S537826
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor E Alfonso Romero-Sandoval
Yingjie Wang,1,2 Yuan Chen,1,2 Yao Yang,1,2 Yanling Zhou,1,2 Yonghui Yang,1 Junchen Zhu1
1Department of Orthopedics, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, People’s Republic of China; 2Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, People’s Republic of China
Correspondence: Yonghui Yang, Email 944588939@qq.com Junchen Zhu, Email 2006zhujc@163.com
Background: Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by progressive cartilage degradation and inflammation, often leading to pain and reduced mobility. Current therapeutic approaches, including pharmacological and surgical interventions, provide symptomatic relief but rarely address the underlying pathological mechanisms effectively. Acupotomy therapy, a minimally invasive technique integrating traditional Chinese medicine and modern surgical concepts, has shown promise in alleviating KOA symptoms. However, its mechanisms, particularly concerning chondrocyte pyroptosis, remain underexplored. This study investigates the role of acupotomy therapy in modulating chondrocyte pyroptosis via the NLRP3/Caspase-1/GSDMD signaling pathway in a rabbit KOA model.
Methods: Forty New Zealand rabbits were randomized into four groups: control, model, acupotomy, and drug-treated groups. A KOA model was induced via intra-articular injection of papain. Interventions included acupotomy therapy and oral celecoxib. Outcomes were assessed using behavioral scoring, micro-CT imaging, histological staining, serum inflammatory markers (ELISA), and the expression of NLRP3 inflammasome-associated proteins (qPCR and Western blot).
Results: Acupotomy therapy significantly improved behavioral scores and reduced knee joint space narrowing. Histological analyses revealed improved cartilage integrity and decreased inflammatory markers. Expression levels of NLRP3, Caspase-1, ASC, and GSDMD were downregulated in the acupotomy group compared to the model group.
Conclusion: This study highlights the therapeutic potential of acupotomy therapy in alleviating KOA symptoms and reducing chondrocyte pyroptosis by modulating the NLRP3 inflammasome pathway. These findings provide a mechanistic basis for its application in KOA treatment and a foundation for further clinical exploration.
Keywords: acupotomy, knee osteoarthritis, cartilage, cellular charring, NLRP3/Caspase-1/GSDMD pathway
1Department of Orthopedics, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, People’s Republic of China; 2Graduate School, Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, People’s Republic of China
Correspondence: Yonghui Yang, Email 944588939@qq.com Junchen Zhu, Email 2006zhujc@163.com
Background: Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by progressive cartilage degradation and inflammation, often leading to pain and reduced mobility. Current therapeutic approaches, including pharmacological and surgical interventions, provide symptomatic relief but rarely address the underlying pathological mechanisms effectively. Acupotomy therapy, a minimally invasive technique integrating traditional Chinese medicine and modern surgical concepts, has shown promise in alleviating KOA symptoms. However, its mechanisms, particularly concerning chondrocyte pyroptosis, remain underexplored. This study investigates the role of acupotomy therapy in modulating chondrocyte pyroptosis via the NLRP3/Caspase-1/GSDMD signaling pathway in a rabbit KOA model.
Methods: Forty New Zealand rabbits were randomized into four groups: control, model, acupotomy, and drug-treated groups. A KOA model was induced via intra-articular injection of papain. Interventions included acupotomy therapy and oral celecoxib. Outcomes were assessed using behavioral scoring, micro-CT imaging, histological staining, serum inflammatory markers (ELISA), and the expression of NLRP3 inflammasome-associated proteins (qPCR and Western blot).
Results: Acupotomy therapy significantly improved behavioral scores and reduced knee joint space narrowing. Histological analyses revealed improved cartilage integrity and decreased inflammatory markers. Expression levels of NLRP3, Caspase-1, ASC, and GSDMD were downregulated in the acupotomy group compared to the model group.
Conclusion: This study highlights the therapeutic potential of acupotomy therapy in alleviating KOA symptoms and reducing chondrocyte pyroptosis by modulating the NLRP3 inflammasome pathway. These findings provide a mechanistic basis for its application in KOA treatment and a foundation for further clinical exploration.
Keywords: acupotomy, knee osteoarthritis, cartilage, cellular charring, NLRP3/Caspase-1/GSDMD pathway