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已发表论文
一例罕见的假结核耶尔森菌感染伴感染性休克及脾梗死病例
Authors Tan Y, Li X, Xie Y, Zhang Z, Liu J, Zhou G, Liu M
Received 20 June 2025
Accepted for publication 12 September 2025
Published 22 September 2025 Volume 2025:18 Pages 5057—5065
DOI https://doi.org/10.2147/IDR.S548492
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hemant Joshi
Yayuan Tan,1 Xueli Li,1 Yingchun Xie,2 Zhaohui Zhang,1 Jinglan Liu,1 Gaosheng Zhou,1 Min Liu1
1Department of Emergency and Critical Care Medicine, the First Clinical Medical College of China Three Gorges University, Yichang Central People’s Hospital, Yichang, People’s Republic of China; 2Department of Radiological Intervention, the First Clinical Medical College of China Three Gorges University, Yichang Central People’s Hospital, Yichang, People’s Republic of China
Correspondence: Min Liu, Department of Emergency and Critical Care Medicine, the First Clinical Medical College of China Three Gorges University, Yichang, Central People’s Hospital, Yichang, 443000, People’s Republic of China, Email 13886726680@163.com
Abstract: Yersinia pseudotuberculosis is a Gram-negative bacterium of the family Yersiniaceae, primarily transmitted via the gastrointestinal tract. Progression to sepsis is uncommon, and the combination of septic shock and splenic infarction is exceedingly rare. We report a 40-year-old male who initially presented with fever, abdominal pain, and distension, which rapidly progressed to sepsis and multi-organ dysfunction. Definitive diagnosis of Y. pseudotuberculosis infection was established by blood culture and metagenomic next-generation sequencing, supported by imaging evidence of splenic infarction. The patient was managed with stepwise antimicrobial regimens (including piperacillin–tazobactam, meropenem, levofloxacin, linezolid, and daptomycin), plasma exchange, continuous renal replacement therapy, and organ function support. Following comprehensive treatment, the patient recovered and was discharged in stable condition. This case highlights the importance of considering Y. pseudotuberculosis in atypical sepsis presentations and demonstrates that timely diagnosis and multidisciplinary management are crucial to improving outcomes in such rare and life-threatening infections.
Keywords: yersinia pseudotuberculosis, septic shock, splenic infarction, case report, nursing
1Department of Emergency and Critical Care Medicine, the First Clinical Medical College of China Three Gorges University, Yichang Central People’s Hospital, Yichang, People’s Republic of China; 2Department of Radiological Intervention, the First Clinical Medical College of China Three Gorges University, Yichang Central People’s Hospital, Yichang, People’s Republic of China
Correspondence: Min Liu, Department of Emergency and Critical Care Medicine, the First Clinical Medical College of China Three Gorges University, Yichang, Central People’s Hospital, Yichang, 443000, People’s Republic of China, Email 13886726680@163.com
Abstract: Yersinia pseudotuberculosis is a Gram-negative bacterium of the family Yersiniaceae, primarily transmitted via the gastrointestinal tract. Progression to sepsis is uncommon, and the combination of septic shock and splenic infarction is exceedingly rare. We report a 40-year-old male who initially presented with fever, abdominal pain, and distension, which rapidly progressed to sepsis and multi-organ dysfunction. Definitive diagnosis of Y. pseudotuberculosis infection was established by blood culture and metagenomic next-generation sequencing, supported by imaging evidence of splenic infarction. The patient was managed with stepwise antimicrobial regimens (including piperacillin–tazobactam, meropenem, levofloxacin, linezolid, and daptomycin), plasma exchange, continuous renal replacement therapy, and organ function support. Following comprehensive treatment, the patient recovered and was discharged in stable condition. This case highlights the importance of considering Y. pseudotuberculosis in atypical sepsis presentations and demonstrates that timely diagnosis and multidisciplinary management are crucial to improving outcomes in such rare and life-threatening infections.
Keywords: yersinia pseudotuberculosis, septic shock, splenic infarction, case report, nursing