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已发表论文
老年 2 型糖尿病患者中低循环代谢素水平与腹部脂肪增多有关：一项基于性别的研究
Authors Pei J, Zhao D, Ye X, Du Y
Received 13 June 2025
Accepted for publication 1 September 2025
Published 22 September 2025 Volume 2025:18 Pages 3601—3609
DOI https://doi.org/10.2147/DMSO.S546457
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Hillary Keenan
Jiangli Pei, Dan Zhao, Xinhua Ye, Yunfeng Du
Department of Endocrinology, the Second People’s Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University., Changzhou, Jiangsu Province, People’s Republic of China
Correspondence: Yunfeng Du, Email fengyundu@njmu.edu.cn
Objective: Our study aimed to investigate the association between serum Metrnl levels and body fat distribution in type 2 diabetes mellitus (T2DM) patients.
Methodology: A total of 281 Chinese patients with type 2 diabetes mellitus (T2DM) (195 men and 86 postmenopausal women, aged 61.37 ± 6.50 years, BMI 24.88 ± 3.10 kg/m²) were included in the study. Measurements of body composition were obtained by dual-energy X-ray absorptiometry. Univariate and multivariate regression analyses were adjusted for age, sex, body mass index (BMI), and lipid levels, specifically android (waist/abdominal-dominant) and gynoid (hip/thigh-dominant) fat deposition. Gender-stratified analyses and restricted cubic spline models were employed.
Results: Serum Metrnl negatively correlated with A/G ratio (β = − 0.01; 95% CI: − 0.02~0.00) and android fat (β = − 0.77; 95% CI: − 1.11~-0.42). After adjustments, associations with A/G and android fat persisted, but not with gynoid fat (P > 0.05). Gender analysis showed stronger correlations in males (A/G: β = − 0.02; 95% CI: − 0.04~-0.01; android fat: β = − 0.85; − 1.28~-0.43), but not females.
Conclusion: Lower serum levels of Metrnl were significantly associated with increased abdominal adiposity in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM), with a more pronounced correlation observed in males. These findings suggest that Metrnl may play a role in regulating abdominal obesity and metabolic dysfunction in this demographic.
Keywords: type 2 diabetes mellitus, metrnl, body fat distribution, lipid metabolism
Department of Endocrinology, the Second People’s Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University., Changzhou, Jiangsu Province, People’s Republic of China
Correspondence: Yunfeng Du, Email fengyundu@njmu.edu.cn
Objective: Our study aimed to investigate the association between serum Metrnl levels and body fat distribution in type 2 diabetes mellitus (T2DM) patients.
Methodology: A total of 281 Chinese patients with type 2 diabetes mellitus (T2DM) (195 men and 86 postmenopausal women, aged 61.37 ± 6.50 years, BMI 24.88 ± 3.10 kg/m²) were included in the study. Measurements of body composition were obtained by dual-energy X-ray absorptiometry. Univariate and multivariate regression analyses were adjusted for age, sex, body mass index (BMI), and lipid levels, specifically android (waist/abdominal-dominant) and gynoid (hip/thigh-dominant) fat deposition. Gender-stratified analyses and restricted cubic spline models were employed.
Results: Serum Metrnl negatively correlated with A/G ratio (β = − 0.01; 95% CI: − 0.02~0.00) and android fat (β = − 0.77; 95% CI: − 1.11~-0.42). After adjustments, associations with A/G and android fat persisted, but not with gynoid fat (P > 0.05). Gender analysis showed stronger correlations in males (A/G: β = − 0.02; 95% CI: − 0.04~-0.01; android fat: β = − 0.85; − 1.28~-0.43), but not females.
Conclusion: Lower serum levels of Metrnl were significantly associated with increased abdominal adiposity in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM), with a more pronounced correlation observed in males. These findings suggest that Metrnl may play a role in regulating abdominal obesity and metabolic dysfunction in this demographic.
Keywords: type 2 diabetes mellitus, metrnl, body fat distribution, lipid metabolism