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已发表论文
立体定向体部放射治疗肝恶性肿瘤中与呼吸运动管理技术相关的摆位误差回顾性评估
Authors Han JH, He DC, Zhang XY, Zhang Y, Hong J, Shi TT, Zhu ZJ
Received 23 June 2025
Accepted for publication 7 September 2025
Published 20 September 2025 Volume 2025:12 Pages 2139—2147
DOI https://doi.org/10.2147/JHC.S546967
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Mohamed Shaker
Ji-Hua Han,* Dong-Cheng He,* Xiao-Ye Zhang, Yan Zhang, Jun Hong, Ting-Ting Shi, Zhi-Jian Zhu
Department of Radiation Oncology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu Province, 223300, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhi-Jian Zhu, Department of Radiation Oncology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huaiyin District, Huai’an, Jiangsu Province, 223300, People’s Republic of China, Tel +86-517-80872759, Email zhuzjhayy@163.com
Objective: This study aimed to evaluate setup errors associated with three respiratory motion management techniques in stereotactic body radiation therapy (SBRT) for individuals with hepatic malignancies.
Methods: A retrospective analysis was conducted on data from 55 individuals with hepatic malignancies who underwent SBRT. Respiratory motion was managed using the Active Breathing Coordinator (ABC) in 11 cases, the BodyFIX system in 6 cases, and a thermoplastic body film combined with an airbag in 38 cases. Cone-beam computed tomography (CBCT) was conducted prior to each treatment session and registered with the reference computed tomography (CT) images acquired during the treatment planning phase to quantify setup errors in three dimensions: left-right (LR), superior-inferior (SI), and anterior-posterior (AP).
Results: In the LR direction, the BodyFIX group had a 1.07 mm lower setup error than the ABC group, and the airbag group showed a 2.13 mm reduction compared to ABC and 1.06 mm compared to BodyFIX. In the SI direction, BodyFIX showed a 4.66 mm reduction and the airbag group a 5.45 mm reduction versus ABC. In the AP direction, reductions were 1.99 mm for BodyFIX and 2.86 mm for the airbag group compared to ABC. All differences were statistically significant. The airbag group also had relatively small planning target volume (PTV) margins.
Conclusion: The airbag-based respiratory motion management technique demonstrated superior positioning accuracy, improved reproducibility, and the potential for PTV margin reduction in SBRT for hepatic malignancies. Further investigations are needed to verify the superiority of this approach in different populations and settings.
Keywords: hepatic malignancies, motion management, PTV margin, setup error
Department of Radiation Oncology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu Province, 223300, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Zhi-Jian Zhu, Department of Radiation Oncology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huaiyin District, Huai’an, Jiangsu Province, 223300, People’s Republic of China, Tel +86-517-80872759, Email zhuzjhayy@163.com
Objective: This study aimed to evaluate setup errors associated with three respiratory motion management techniques in stereotactic body radiation therapy (SBRT) for individuals with hepatic malignancies.
Methods: A retrospective analysis was conducted on data from 55 individuals with hepatic malignancies who underwent SBRT. Respiratory motion was managed using the Active Breathing Coordinator (ABC) in 11 cases, the BodyFIX system in 6 cases, and a thermoplastic body film combined with an airbag in 38 cases. Cone-beam computed tomography (CBCT) was conducted prior to each treatment session and registered with the reference computed tomography (CT) images acquired during the treatment planning phase to quantify setup errors in three dimensions: left-right (LR), superior-inferior (SI), and anterior-posterior (AP).
Results: In the LR direction, the BodyFIX group had a 1.07 mm lower setup error than the ABC group, and the airbag group showed a 2.13 mm reduction compared to ABC and 1.06 mm compared to BodyFIX. In the SI direction, BodyFIX showed a 4.66 mm reduction and the airbag group a 5.45 mm reduction versus ABC. In the AP direction, reductions were 1.99 mm for BodyFIX and 2.86 mm for the airbag group compared to ABC. All differences were statistically significant. The airbag group also had relatively small planning target volume (PTV) margins.
Conclusion: The airbag-based respiratory motion management technique demonstrated superior positioning accuracy, improved reproducibility, and the potential for PTV margin reduction in SBRT for hepatic malignancies. Further investigations are needed to verify the superiority of this approach in different populations and settings.
Keywords: hepatic malignancies, motion management, PTV margin, setup error