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已发表论文
针刺治疗神经根型颈椎病的应用：基于病理生理基础和治疗机制的深入分析与展望
Received 28 June 2025
Accepted for publication 27 August 2025
Published 20 September 2025 Volume 2025:18 Pages 5717—5730
DOI https://doi.org/10.2147/IJGM.S550285
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Yuehua Li, Qingxi Cao
Department of Sports Medicine, The People’s Hospital of Baoan Shenzhen, Shenzhen, Guangdong Province, People’s Republic of China
Correspondence: Qingxi Cao, Email a13316592166@126.com
Abstract: Cervical Spondylotic Radiculopathy (CSR) is a debilitating condition caused by nerve root compression from degenerative cervical changes, leading to pain and dysfunction. Acupuncture, a key non-pharmacological treatment, shows significant clinical promise, yet its biological mechanisms are not fully understood. This article analyzes CSR’s pathophysiology and acupuncture’s therapeutic actions, based on literature published between 2010 and 2025, with a focus on recent key advancements. The review covers CSR’s pathology, including mechanical compression, neuro-inflammation (eg, TNF-α), and neural sensitization. It then elucidates acupuncture’s mechanisms: central analgesia via endogenous opioids (eg, β-endorphin), downregulation of pro-inflammatory mediators, enhanced local microcirculation, and modulation of oxidative stress. In conclusion, acupuncture intervenes in CSR’s pathology through a multi-target neuro-immune-circulatory network. Future high-quality clinical trials and deeper molecular studies are essential to provide robust scientific evidence for its clinical application.
Keywords: acupuncture, cervical spondylotic radiculopathy, nerve root inflammation, pathophysiology, central sensitization
Department of Sports Medicine, The People’s Hospital of Baoan Shenzhen, Shenzhen, Guangdong Province, People’s Republic of China
Correspondence: Qingxi Cao, Email a13316592166@126.com
Abstract: Cervical Spondylotic Radiculopathy (CSR) is a debilitating condition caused by nerve root compression from degenerative cervical changes, leading to pain and dysfunction. Acupuncture, a key non-pharmacological treatment, shows significant clinical promise, yet its biological mechanisms are not fully understood. This article analyzes CSR’s pathophysiology and acupuncture’s therapeutic actions, based on literature published between 2010 and 2025, with a focus on recent key advancements. The review covers CSR’s pathology, including mechanical compression, neuro-inflammation (eg, TNF-α), and neural sensitization. It then elucidates acupuncture’s mechanisms: central analgesia via endogenous opioids (eg, β-endorphin), downregulation of pro-inflammatory mediators, enhanced local microcirculation, and modulation of oxidative stress. In conclusion, acupuncture intervenes in CSR’s pathology through a multi-target neuro-immune-circulatory network. Future high-quality clinical trials and deeper molecular studies are essential to provide robust scientific evidence for its clinical application.
Keywords: acupuncture, cervical spondylotic radiculopathy, nerve root inflammation, pathophysiology, central sensitization