108139
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
关于 2 型糖尿病患者内脏脂肪指数、脂肪肝指数与甲状腺功能障碍相关性的研究
Authors Zheng B, Hu T, Yao J, Zhang Z, Xu Y, Shen H, Wang X, Tan Q
Received 4 June 2025
Accepted for publication 19 August 2025
Published 19 September 2025 Volume 2025:18 Pages 3553—3562
DOI https://doi.org/10.2147/DMSO.S544669
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rebecca Baqiyyah Conway
Bojing Zheng,* Tianxiao Hu,* Jiaqi Yao, Zhenying Zhang, Yao Xu, Huiling Shen, Xiujing Wang, Qingying Tan
Department of Endocrinology, 903rd Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army, Hangzhou, Zhejiang Province, 310013, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiujing Wang; Qingying Tan, Department of Endocrinology, 903rd Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army, Hangzhou, Zhejiang Province, 310013, People’s Republic of China, Email wangxjzju@sina.com; tanqy1973@163.com
Objective: This study explores the correlations between visceral adiposity index, fatty liver indices and thyroid dysfunction in type 2 diabetes mellitus patients.
Methods: This cross-sectional investigation was carried out between January 2021 and December 2022, encompassing 131 adult out-patients. Patients with other endocrine diseases, severe hepatic or renal insufficiency, or recent use of thyroid-affecting medications were excluded. Clinical and laboratory data, including body mass index, waist circumference, lipid profiles, liver function markers, and thyroid function tests, were collected.
Results: Blood tests showed hepatic injury markers, alanine aminotransferase, aspartate aminotransferase, and adverse lipid profiles, elevated triglycerides, reduced high-density lipoprotein, significantly increased across fatty liver indices quartiles (P < 0.05), reflecting hepatocellular injury. Waist circumference and body mass index also increased significantly with higher fatty liver indices quartiles. Similarly, visceral adiposity index showed strong correlations with metabolic parameters, including elevated alanine aminotransferase, aspartate aminotransferase, and triglycerides levels (P < 0.05). Regarding thyroid function, TSH levels increased to some extent (P = 0.068), suggesting a potential link between fatty liver and hypothyroidism.
Conclusion: This study highlights the significant role of visceral fat accumulation and liver fat deposition in contributing to insulin resistance and metabolic imbalances among individuals with type 2 diabetes. Clinicians and public health departments should promote early identification and intervention of visceral fat accumulation and fatty liver as tools to prevent metabolic syndrome and related diseases.
Keywords: type 2 diabetes mellitus, visceral adiposity index, fatty liver index, thyroid dysfunction, metabolic disorders
Department of Endocrinology, 903rd Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army, Hangzhou, Zhejiang Province, 310013, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiujing Wang; Qingying Tan, Department of Endocrinology, 903rd Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation Army, Hangzhou, Zhejiang Province, 310013, People’s Republic of China, Email wangxjzju@sina.com; tanqy1973@163.com
Objective: This study explores the correlations between visceral adiposity index, fatty liver indices and thyroid dysfunction in type 2 diabetes mellitus patients.
Methods: This cross-sectional investigation was carried out between January 2021 and December 2022, encompassing 131 adult out-patients. Patients with other endocrine diseases, severe hepatic or renal insufficiency, or recent use of thyroid-affecting medications were excluded. Clinical and laboratory data, including body mass index, waist circumference, lipid profiles, liver function markers, and thyroid function tests, were collected.
Results: Blood tests showed hepatic injury markers, alanine aminotransferase, aspartate aminotransferase, and adverse lipid profiles, elevated triglycerides, reduced high-density lipoprotein, significantly increased across fatty liver indices quartiles (P < 0.05), reflecting hepatocellular injury. Waist circumference and body mass index also increased significantly with higher fatty liver indices quartiles. Similarly, visceral adiposity index showed strong correlations with metabolic parameters, including elevated alanine aminotransferase, aspartate aminotransferase, and triglycerides levels (P < 0.05). Regarding thyroid function, TSH levels increased to some extent (P = 0.068), suggesting a potential link between fatty liver and hypothyroidism.
Conclusion: This study highlights the significant role of visceral fat accumulation and liver fat deposition in contributing to insulin resistance and metabolic imbalances among individuals with type 2 diabetes. Clinicians and public health departments should promote early identification and intervention of visceral fat accumulation and fatty liver as tools to prevent metabolic syndrome and related diseases.
Keywords: type 2 diabetes mellitus, visceral adiposity index, fatty liver index, thyroid dysfunction, metabolic disorders