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已发表论文
抗菌肽在伤口敷料中的应用
Authors Zhu A, Chen B, Ma J, Wang J, Tang R, Liu L, Sun W, Zheng X, Pan G
Received 28 May 2025
Accepted for publication 2 September 2025
Published 19 September 2025 Volume 2025:19 Pages 8523—8539
DOI https://doi.org/10.2147/DDDT.S543233
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Tamer Ibrahim
Aoxun Zhu,1,2,* Baiqi Chen,3,* Jing Ma,4 Jiajia Wang,1,2 Rongfang Tang,1,2 Liangeng Liu,1,2 Weixin Sun,1,2 Xingzhong Zheng,1,2 Guangtao Pan1,2,5
1Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu, 224000, People’s Republic of China; 2Yancheng Hospital of Traditional Chinese Medicine, Yancheng, Jiangsu, 224000, People’s Republic of China; 3Yancheng NO.1 People’s Hospital, Yancheng, Jiangsu, 224000, People’s Republic of China; 4Xiangshui County Hospital of Traditional Chinese Medicine, Yancheng, Jiangsu, 224000, People’s Republic of China; 5School of Chinese Medicine, Macau University of Science and Technology, Cotai, Macau, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guangtao Pan, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine (Yancheng Hospital of Traditional Chinese Medicine), Yancheng, Jiangsu, 224000, People’s Republic of China, Email panguangtaowuhan@foxmail.com Xingzhong Zheng, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine (Yancheng Hospital of Traditional Chinese Medicine), Yancheng, Jiangsu, 224000, People’s Republic of China, Email zhengxingzhongzyy@163.com
Background: Growing antibiotic misuse and the rise of antimicrobial resistance have driven interest in antimicrobial peptides (AMPs) as therapeutic agents for wound dressings and clinical wound management. AMPs are short, cationic peptides with broad spectrum activity and diverse mechanisms of action that confer a low propensity for resistance development.
Methods: We performed a focused literature synthesis to review AMP classification, structural features, antimicrobial mechanisms, and strategies for integrating AMPs into wound dressings. We emphasize materials and delivery approaches reported for hydrogels, electrospun fibers, films, scaffolds, and sponges, and we summarize advances in hybrid systems that combine AMPs with functional materials.
Results: AMP loaded dressings promote infection control and tissue repair by maintaining a favorable wound microenvironment, enabling controlled peptide release, reducing biofilms, and stimulating cell proliferation and angiogenesis. Hybrid platforms—polysaccharide and stimuli responsive hydrogels, metal nanoparticle composites, exosome carriers, and cryogels—improve peptide stability and bioavailability while introducing functionalities such as real time bacterial sensing, antioxidant activity, and electrical conductivity for electrostimulation. In chronic wounds and burns, AMP based dressings show promise for anti biofilm activity, immunomodulation, enhanced re epithelialization, and reduced risk of resistance compared with conventional antibiotics.
Conclusion: We identify key challenges and propose future directions: rational design of tailored AMPs, smart controlled release carriers, nanotechnology enabled formulations, and strategies to accelerate clinical translation. Advances in these areas are expected to expedite the clinical adoption of AMP based wound therapies, offering safer, more effective, and personalized treatment options.
Keywords: antibiotics, antimicrobial peptides, wound healing, bacterial infection, drug resistance, wound dressings, antimicrobial materials
1Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu, 224000, People’s Republic of China; 2Yancheng Hospital of Traditional Chinese Medicine, Yancheng, Jiangsu, 224000, People’s Republic of China; 3Yancheng NO.1 People’s Hospital, Yancheng, Jiangsu, 224000, People’s Republic of China; 4Xiangshui County Hospital of Traditional Chinese Medicine, Yancheng, Jiangsu, 224000, People’s Republic of China; 5School of Chinese Medicine, Macau University of Science and Technology, Cotai, Macau, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guangtao Pan, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine (Yancheng Hospital of Traditional Chinese Medicine), Yancheng, Jiangsu, 224000, People’s Republic of China, Email panguangtaowuhan@foxmail.com Xingzhong Zheng, Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine (Yancheng Hospital of Traditional Chinese Medicine), Yancheng, Jiangsu, 224000, People’s Republic of China, Email zhengxingzhongzyy@163.com
Background: Growing antibiotic misuse and the rise of antimicrobial resistance have driven interest in antimicrobial peptides (AMPs) as therapeutic agents for wound dressings and clinical wound management. AMPs are short, cationic peptides with broad spectrum activity and diverse mechanisms of action that confer a low propensity for resistance development.
Methods: We performed a focused literature synthesis to review AMP classification, structural features, antimicrobial mechanisms, and strategies for integrating AMPs into wound dressings. We emphasize materials and delivery approaches reported for hydrogels, electrospun fibers, films, scaffolds, and sponges, and we summarize advances in hybrid systems that combine AMPs with functional materials.
Results: AMP loaded dressings promote infection control and tissue repair by maintaining a favorable wound microenvironment, enabling controlled peptide release, reducing biofilms, and stimulating cell proliferation and angiogenesis. Hybrid platforms—polysaccharide and stimuli responsive hydrogels, metal nanoparticle composites, exosome carriers, and cryogels—improve peptide stability and bioavailability while introducing functionalities such as real time bacterial sensing, antioxidant activity, and electrical conductivity for electrostimulation. In chronic wounds and burns, AMP based dressings show promise for anti biofilm activity, immunomodulation, enhanced re epithelialization, and reduced risk of resistance compared with conventional antibiotics.
Conclusion: We identify key challenges and propose future directions: rational design of tailored AMPs, smart controlled release carriers, nanotechnology enabled formulations, and strategies to accelerate clinical translation. Advances in these areas are expected to expedite the clinical adoption of AMP based wound therapies, offering safer, more effective, and personalized treatment options.
Keywords: antibiotics, antimicrobial peptides, wound healing, bacterial infection, drug resistance, wound dressings, antimicrobial materials