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已发表论文
开启成功之门：正常反应的体外受精患者黄体期促性腺激素刺激的最佳起始剂量
Authors Nie X , Wang Q, Xu M, Dai R, Pang B , Hu C
Received 14 May 2025
Accepted for publication 12 September 2025
Published 19 September 2025 Volume 2025:17 Pages 3119—3131
DOI https://doi.org/10.2147/IJWH.S540342
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Xinyu Nie,1,2 Qi Wang,1,3 Mengmeng Xu,4 Rulin Dai,1 Bo Pang,5 Cong Hu1
1Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Gynecology, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, People’s Republic of China; 3Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Rehabilitation medicine, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 5Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
Correspondence: Bo Pang, Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin Province, 130000, People’s Republic of China, Email bopang@jlu.edu.cn Cong Hu, Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jilin Province, 130000, People’s Republic of China, Email conghu@jlu.edu.cn
Purpose: To analyze and discover the optimal gonadotrophin (Gn) starting point for luteal-phase stimulation (LPS) in in vitro fertilization (IVF) Patients with normal ovarian response (NOR).
Patients and Methods: A total of 199 IVF or intracytoplasmic sperm injection (ICSI) cycles performed at the Reproductive Center of the First Hospital of Jilin University from January 1, 2021, to December 31, 2023, were recruited in the study. Of these, 121 cycles followed the follicular phase ovarian stimulation (FPS) (119 cases of adding antagonists), while 78 cycles adhered to the LPS protocol. The LPS group was divided into three subgroups based on the timing of Gn initiation: early, mid-, and late LPS. Comparisons were made between the LPS and FPS groups, as well as among the three subgroups, regarding Gn duration, total Gn dose, number of oocytes retrieved, number of embryos, rate of good-quality embryos, blastocyst formation rate, clinical pregnancy rate, cumulative pregnancy rate, live birth rate and cumulative live birth rate.
Results: The rate of high-quality embryos in the late luteal phase was significantly higher than that in the early luteal group and slightly higher than that in the mid-luteal group. The clinical pregnancy rate and live birth rate of the late luteal group were slightly higher than those of the early and mid-luteal group, and were not significantly different from those of the FPS group.
Conclusion: Initiating Gn stimulation during the late luteal-phase appears to be the optimal timing in NOR patients.
Keywords: luteal phase ovarian stimulation, follicular phase ovarian stimulation, normal ovarian response, timing of gonadotropin initiation, pregnancy outcome
1Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Gynecology, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, People’s Republic of China; 3Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Rehabilitation medicine, First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 5Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
Correspondence: Bo Pang, Department of Cardiology, The First Hospital of Jilin University, Changchun, Jilin Province, 130000, People’s Republic of China, Email bopang@jlu.edu.cn Cong Hu, Reproductive Medicine Center, Prenatal Diagnosis Center, First Hospital of Jilin University, Changchun, Jilin Province, 130000, People’s Republic of China, Email conghu@jlu.edu.cn
Purpose: To analyze and discover the optimal gonadotrophin (Gn) starting point for luteal-phase stimulation (LPS) in in vitro fertilization (IVF) Patients with normal ovarian response (NOR).
Patients and Methods: A total of 199 IVF or intracytoplasmic sperm injection (ICSI) cycles performed at the Reproductive Center of the First Hospital of Jilin University from January 1, 2021, to December 31, 2023, were recruited in the study. Of these, 121 cycles followed the follicular phase ovarian stimulation (FPS) (119 cases of adding antagonists), while 78 cycles adhered to the LPS protocol. The LPS group was divided into three subgroups based on the timing of Gn initiation: early, mid-, and late LPS. Comparisons were made between the LPS and FPS groups, as well as among the three subgroups, regarding Gn duration, total Gn dose, number of oocytes retrieved, number of embryos, rate of good-quality embryos, blastocyst formation rate, clinical pregnancy rate, cumulative pregnancy rate, live birth rate and cumulative live birth rate.
Results: The rate of high-quality embryos in the late luteal phase was significantly higher than that in the early luteal group and slightly higher than that in the mid-luteal group. The clinical pregnancy rate and live birth rate of the late luteal group were slightly higher than those of the early and mid-luteal group, and were not significantly different from those of the FPS group.
Conclusion: Initiating Gn stimulation during the late luteal-phase appears to be the optimal timing in NOR patients.
Keywords: luteal phase ovarian stimulation, follicular phase ovarian stimulation, normal ovarian response, timing of gonadotropin initiation, pregnancy outcome