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已发表论文
肺切除术后利多卡因基础与舒芬太尼基础自控静脉镇痛：一项随机对照试验
Authors Tian B, Wu Y, Zhang W, Liu R, Qu S, Zhang Z , Yan W
Received 3 May 2025
Accepted for publication 29 August 2025
Published 19 September 2025 Volume 2025:19 Pages 8541—8553
DOI https://doi.org/10.2147/DDDT.S538226
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Anastasios Lymperopoulos
Bin Tian,1,* Yumin Wu,2,* Wenjie Zhang,3 Ruijuan Liu,1 Song Qu,4 Zhenying Zhang,1 Wenjun Yan1
1Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, People’s Republic of China; 2Department of Anesthesiology, Nanzhang People’s Hospital, Xiangyang, People’s Republic of China; 3Department of Anesthesiology, Affiliated Hospital of Shandong Second Medical University, Weifang, People’s Republic of China; 4Department of Anesthesiology, Guian Hospital The Affiliated Hospital of Guizhou Medical University, GuiYang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenjun Yan, Department of Anesthesiology, Gansu Provincial Hospital, 204 Donggang West Road, Chengguan District, Lanzhou, Gansu, People’s Republic of China, Email 13893370700@163.com
Background: We investigated the efficacy and safety of lidocaine-based patient-controlled intravenous analgesia (PCIA), compared with sufentanil-based PCIA on postoperative pain and recovery quality in patients undergoing thoracoscopic lung surgery.
Methods: We recruited 160 patients undergoing thoracoscopic lung surgery who were randomized to receive lidocaine-based PCIA (1.5 mg/kg/h) or sufentanil-based PCIA (2 μg/mL) within 48 hours postoperatively. The primary endpoint was visual analogue scores (VAS) pain scores at 6, 12, 24, and 48 hours postoperatively. Postoperative quality of recovery-15 (QoR-15) scores and other prespecified endpoints were also recorded.
Results: VAS pain scores at rest and during coughing in the lidocaine group were significantly lower at 6, 12, and 24 hours postoperatively (P< 0.05), with no difference at 48 hours (P> 0.05). QoR-15 scores in the lidocaine group were higher on postoperative day (POD) 1 (P< 0.001) and POD2 (P< 0.001), with significant differences in the two dimensions of postoperative physical comfort and pain (P< 0.001). The lidocaine group also experienced a shorter time to first flatus, defecation, and ambulation (P< 0.05), with no difference in the length of postoperative hospitalization and thoracic drainage time (P> 0.05). The serum IL-6, TNF-α, IL-8, cortisol, and epinephrine concentrations were lower in the lidocaine group on POD1 and POD2 (P< 0.05). The incidence of postoperative nausea and vomiting in the lidocaine group was lower (P< 0.05), with no differences in other adverse events (P> 0.05).
Conclusion: Compared with sufentanil-based PCIA, lidocaine-based PCIA significantly relieved postoperative pain and improved recovery quality after thoracoscopic lung surgery with fewer postoperative adverse events, which is a considerable choice for postoperative analgesia.
Trial Registration: This study was retrospectively registered at the Chinese Clinical Trial Registry on March 1st, 2023 (number ChiCTR2300068840).
Keywords: thoracoscopic lung surgery, intravenous lidocaine, postoperative analgesia, quality of recovery
1Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou, People’s Republic of China; 2Department of Anesthesiology, Nanzhang People’s Hospital, Xiangyang, People’s Republic of China; 3Department of Anesthesiology, Affiliated Hospital of Shandong Second Medical University, Weifang, People’s Republic of China; 4Department of Anesthesiology, Guian Hospital The Affiliated Hospital of Guizhou Medical University, GuiYang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenjun Yan, Department of Anesthesiology, Gansu Provincial Hospital, 204 Donggang West Road, Chengguan District, Lanzhou, Gansu, People’s Republic of China, Email 13893370700@163.com
Background: We investigated the efficacy and safety of lidocaine-based patient-controlled intravenous analgesia (PCIA), compared with sufentanil-based PCIA on postoperative pain and recovery quality in patients undergoing thoracoscopic lung surgery.
Methods: We recruited 160 patients undergoing thoracoscopic lung surgery who were randomized to receive lidocaine-based PCIA (1.5 mg/kg/h) or sufentanil-based PCIA (2 μg/mL) within 48 hours postoperatively. The primary endpoint was visual analogue scores (VAS) pain scores at 6, 12, 24, and 48 hours postoperatively. Postoperative quality of recovery-15 (QoR-15) scores and other prespecified endpoints were also recorded.
Results: VAS pain scores at rest and during coughing in the lidocaine group were significantly lower at 6, 12, and 24 hours postoperatively (P< 0.05), with no difference at 48 hours (P> 0.05). QoR-15 scores in the lidocaine group were higher on postoperative day (POD) 1 (P< 0.001) and POD2 (P< 0.001), with significant differences in the two dimensions of postoperative physical comfort and pain (P< 0.001). The lidocaine group also experienced a shorter time to first flatus, defecation, and ambulation (P< 0.05), with no difference in the length of postoperative hospitalization and thoracic drainage time (P> 0.05). The serum IL-6, TNF-α, IL-8, cortisol, and epinephrine concentrations were lower in the lidocaine group on POD1 and POD2 (P< 0.05). The incidence of postoperative nausea and vomiting in the lidocaine group was lower (P< 0.05), with no differences in other adverse events (P> 0.05).
Conclusion: Compared with sufentanil-based PCIA, lidocaine-based PCIA significantly relieved postoperative pain and improved recovery quality after thoracoscopic lung surgery with fewer postoperative adverse events, which is a considerable choice for postoperative analgesia.
Trial Registration: This study was retrospectively registered at the Chinese Clinical Trial Registry on March 1st, 2023 (number ChiCTR2300068840).
Keywords: thoracoscopic lung surgery, intravenous lidocaine, postoperative analgesia, quality of recovery