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已发表论文
血清硒及氧化还原生物标志物在视网膜静脉阻塞中的诊断及预后预测价值
Authors Shen D, Li M, Sun W, Tao Z
Received 3 March 2025
Accepted for publication 18 August 2025
Published 19 September 2025 Volume 2025:18 Pages 5731—5742
DOI https://doi.org/10.2147/IJGM.S522918
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Daniela Opriș-Belinski
Danqing Shen,1,* Meixiu Li,1,* Wencai Sun,2 Zhifu Tao3
1Department of Ophthalmology, Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine (Taicang Hospital of Traditional Chinese Medicine), Taicang, Suzhou, Jiangsu, People’s Republic of China; 2Department of Nephrology, Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine (Taicang Hospital of Traditional Chinese Medicine), Taicang, Suzhou, Jiangsu, People’s Republic of China; 3Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wencai Sun, Email sunwencai7908@sina.com Zhifu Tao, Email zhifutao@suda.edu.cn
Objective: To investigate the diagnostic efficacy and prognostic predictive value of serum selenium (Sse) and redox biomarkers in retinal vein occlusion (RVO).
Methods: A prospective analysis was conducted on 112 RVO patients (RVO Group) admitted to the hospital between January 2022 and February 2024, along with 112 non-RVO ophthalmic patients (non-RVO Group) during the same period. The levels of Sse and redox factors [high mobility group protein B1 (HMGB1), reduced glutathione (GSH), nitric oxide (NO), and superoxide dismutase (SOD)] were compared between the two groups, and the receiver operating characteristic (ROC) curves were plotted to analyze their diagnostic efficacy for RVO. The RVO Group received treatment and was divided into poor prognosis group and good prognosis group based on prognosis. The changes in Sse and redox biomarker levels were compared to analyze factors influencing RVO patient prognosis, and a nomogram was constructed to validate the calibration curve.
Results: Compared with the non-RVO group, the levels of Sse, GSH, and SOD were lower, while the levels of HMGB1 and NO were higher in the RVO group (P < 0.05). The ROC curve showed that Sse and various oxidative stress factors had good diagnostic efficacy for RVO. In the Poor Prognosis Group, Sse, GSH, NO, and SOD levels were lower than those in the Good Prognosis Group, while HMGB1 levels were higher than those in the Good Prognosis Group (P < 0.05). Cox regression analysis showed that all these indicators were factors influencing the prognosis of RVO patients (all P < 0.05). Additionally, the consistency of theroc curves constructed using these factors was good, and the calibration curves were close to the ideal curve.
Conclusion: The combined detection of Sse and redox biomarkers can effectively assist in RVO diagnosis, while their dynamic changes have important clinical value in prognosis evaluation.
Keywords: serum selenium, redox factors, retinal vein occlusion, high mobility group protein B1, reduced glutathione
1Department of Ophthalmology, Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine (Taicang Hospital of Traditional Chinese Medicine), Taicang, Suzhou, Jiangsu, People’s Republic of China; 2Department of Nephrology, Taicang TCM Hospital Affiliated to Nanjing University of Chinese Medicine (Taicang Hospital of Traditional Chinese Medicine), Taicang, Suzhou, Jiangsu, People’s Republic of China; 3Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wencai Sun, Email sunwencai7908@sina.com Zhifu Tao, Email zhifutao@suda.edu.cn
Objective: To investigate the diagnostic efficacy and prognostic predictive value of serum selenium (Sse) and redox biomarkers in retinal vein occlusion (RVO).
Methods: A prospective analysis was conducted on 112 RVO patients (RVO Group) admitted to the hospital between January 2022 and February 2024, along with 112 non-RVO ophthalmic patients (non-RVO Group) during the same period. The levels of Sse and redox factors [high mobility group protein B1 (HMGB1), reduced glutathione (GSH), nitric oxide (NO), and superoxide dismutase (SOD)] were compared between the two groups, and the receiver operating characteristic (ROC) curves were plotted to analyze their diagnostic efficacy for RVO. The RVO Group received treatment and was divided into poor prognosis group and good prognosis group based on prognosis. The changes in Sse and redox biomarker levels were compared to analyze factors influencing RVO patient prognosis, and a nomogram was constructed to validate the calibration curve.
Results: Compared with the non-RVO group, the levels of Sse, GSH, and SOD were lower, while the levels of HMGB1 and NO were higher in the RVO group (P < 0.05). The ROC curve showed that Sse and various oxidative stress factors had good diagnostic efficacy for RVO. In the Poor Prognosis Group, Sse, GSH, NO, and SOD levels were lower than those in the Good Prognosis Group, while HMGB1 levels were higher than those in the Good Prognosis Group (P < 0.05). Cox regression analysis showed that all these indicators were factors influencing the prognosis of RVO patients (all P < 0.05). Additionally, the consistency of theroc curves constructed using these factors was good, and the calibration curves were close to the ideal curve.
Conclusion: The combined detection of Sse and redox biomarkers can effectively assist in RVO diagnosis, while their dynamic changes have important clinical value in prognosis evaluation.
Keywords: serum selenium, redox factors, retinal vein occlusion, high mobility group protein B1, reduced glutathione