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已发表论文
母体亚临床甲状腺功能减退症与双胎妊娠生长不一致之间的关联：一项回顾性研究
Authors Zhang B, Chen X, Zhao X, Wu J, Qi P, Zhang W
Received 26 January 2025
Accepted for publication 18 June 2025
Published 3 October 2025 Volume 2025:17 Pages 3437—3443
DOI https://doi.org/10.2147/IJWH.S519600
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Bing Zhang,1 Xiaoqin Chen,1 Xiaoxiao Zhao,1 Junbao Wu,1 Pan Qi,2 Weixing Zhang1
1Department of Neonatal Intensive Care Unit, Xinxiang Central Hospital, Xinxiang, Henan, 453000, People’s Republic of China; 2Department of Surgical Oncology, Xinxiang Central Hospital, Xinxiang, Henan, 453000, People’s Republic of China
Correspondence: Weixing Zhang, Department of Neonatal Intensive Care Unit, Xinxiang Central Hospital, No. 56 Xinsui Avenue, Xinxiang, Henan, 453000, People’s Republic of China, Email zhangweixing0420@126.com
Purpose: It is reported that there is a growth discordance of at least 20% in about 16% of twin gestations, which may be associated with maternal, fetal, or placental factors. This study was performed to investigate the relationship between maternal subclinical hypothyroidism (SCH) and growth discordance in twin gestations.
Patients and Methods: In this retrospective study, the clinical data of 106 women with twin gestations and their neonates were collected. The effect of maternal SCH on the growth discordance in twin gestations was analyzed using both linear and Logistic regression models.
Results: Among the 106 women enrolled in our study, 48 cases (45.28%) were diagnosed with SCH, and 46 twins (43.40%) experienced growth discordance. Compared with those with smaller weight, the neonates with larger weight had a higher proportion of males (p< 0.001), larger birth weight (p< 0.001), birth height (p=0.009) and birth head circumference (p=0.001). Women with SCH showed a higher proportion of growth discordance (p=0.005) and larger difference in the body weight (p=0.021). Logistic regression analysis showed that maternal SCH was an independent risk factor for birth weight discordance in twins (95% CI: 1.601– 9.425, p=0.003). Linear analysis further revealed that maternal SCH was positively associated with the birth weight difference in twins (95% CI: 0.261– 8.308, p=0.037).
Conclusion: Our findings suggest that maternal SCH may serve as an independent risk factor for birth weight discordance and is positively associated with the birth weight difference in twins.
Keywords: subclinical hypothyroidism, growth discordance, birth weight, twin gestations
1Department of Neonatal Intensive Care Unit, Xinxiang Central Hospital, Xinxiang, Henan, 453000, People’s Republic of China; 2Department of Surgical Oncology, Xinxiang Central Hospital, Xinxiang, Henan, 453000, People’s Republic of China
Correspondence: Weixing Zhang, Department of Neonatal Intensive Care Unit, Xinxiang Central Hospital, No. 56 Xinsui Avenue, Xinxiang, Henan, 453000, People’s Republic of China, Email zhangweixing0420@126.com
Purpose: It is reported that there is a growth discordance of at least 20% in about 16% of twin gestations, which may be associated with maternal, fetal, or placental factors. This study was performed to investigate the relationship between maternal subclinical hypothyroidism (SCH) and growth discordance in twin gestations.
Patients and Methods: In this retrospective study, the clinical data of 106 women with twin gestations and their neonates were collected. The effect of maternal SCH on the growth discordance in twin gestations was analyzed using both linear and Logistic regression models.
Results: Among the 106 women enrolled in our study, 48 cases (45.28%) were diagnosed with SCH, and 46 twins (43.40%) experienced growth discordance. Compared with those with smaller weight, the neonates with larger weight had a higher proportion of males (p< 0.001), larger birth weight (p< 0.001), birth height (p=0.009) and birth head circumference (p=0.001). Women with SCH showed a higher proportion of growth discordance (p=0.005) and larger difference in the body weight (p=0.021). Logistic regression analysis showed that maternal SCH was an independent risk factor for birth weight discordance in twins (95% CI: 1.601– 9.425, p=0.003). Linear analysis further revealed that maternal SCH was positively associated with the birth weight difference in twins (95% CI: 0.261– 8.308, p=0.037).
Conclusion: Our findings suggest that maternal SCH may serve as an independent risk factor for birth weight discordance and is positively associated with the birth weight difference in twins.
Keywords: subclinical hypothyroidism, growth discordance, birth weight, twin gestations